Results 41 to 50 of about 2,556,175 (314)

The drawbacks of advantages

open access: yesMedical Education, 2022
This commentary offers reflection on what is lost when selection interviews move into a virtual space, using Rodriguez et al. to argue that inviting applicants to visit, spend time and “be there” still looks like the best way to consider “fit.”
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modelling home advantage in the Summer Olympic Games. [PDF]

open access: yes, 2007
Home advantage in team games is well proven and the influence of the crowd upon officials' decisions has been identified as a plausible cause. The aim of this study was to assess the significance of home advantage for five event groups selected from the ...
Balmer, Nigel J.   +2 more
core  

ZONA KESESUAIAN LAHAN RAWA PASANG SURUT BERBASIS KEUNGGULAN KOMPETITIF KOMODITAS

open access: yesSepa, 2017
The research was aimed to engineer the agriculture development model in KTM  tidal  swampland  that  based  on  resources  utilization  optimizing  (land,  human,and  material),  agriculture  technology  amelioration  and  farm  zoning  based  on ...
Yanti Rina D, Haris Syahbuddin
doaj   +1 more source

General Opinions about the Adoption of IAS/IFRS in Romania

open access: yesRomanian Economic Journal, 2021
IAS/IFRS represent a set of global accounting standards that have gained a tremendous influence over national standards, regulations and organisations all across the globe.
Dragos Andrei Stoica
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription

open access: yesNature Communications
The persistence of HIV-1 in a latent state within long-lived immune cells remains a major barrier to a cure for HIV-1 infection. The “block-and-lock” strategy aims to silence the HIV-1 provirus permanently using latency promoting agents (LPAs).
Eline Pellaers   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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