Results 201 to 210 of about 14,607 (268)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The "Secret of Seven Stones": Short-Term Efficacy of an Online Intergenerational Sexual Health Education Game for Early Adolescents and Their Parents. [PDF]

Games Health J
Shegog R, Markham C, Peskin M, Addy RC, Dube S, Maria DS, Emery ST, Wilkerson JM, Baumler E, Armistead L, Chaudhary P, Song HY, Spencer A, McLaughlin J.   +13 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluating acute stress responses to height: validity of heart rate variability, respiratory markers, and competitive state anxiety inventory. [PDF]

Front Psychol
Psohlavec L, Rogerson M, Brtník T, Baláš J.   +3 more
europepmc   +1 more source

Characterization of eye blink parameters during high and low-dynamic scenes in different video game genres. [PDF]

J Optom
Argilés M, Cardona G, Valentino M.
europepmc   +1 more source

An Editor-in-Chief's farewell. [PDF]

Can Med Educ J
D'Eon MF.
europepmc   +1 more source

Beyond the cruise ship: Andes hantavirus and the neglected one health dimensions of global outbreak preparedness. [PDF]

Lancet Reg Health Am
Iwu CD, Pettan-Brewer C, Iwu-Jaja C, Rabinowitz P, Meisner J.   +4 more
europepmc   +1 more source

Assessment of ecotourism suitability in Qilian mountain National park. [PDF]

Sci Rep
Huang S, Sheng D, Wang P, Xiao J, Li Q, Liu H.   +5 more
europepmc   +1 more source