Results 71 to 80 of about 4,029,110 (263)

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Adverse childhood experiences and associations with health-harming behaviours in young adults: surveys in eight eastern European countries

Bulletin of the World Health Organization
Objective To evaluate the association between adverse childhood experiences – e.g. abuse, neglect, domestic violence and parental separation, substance use, mental illness or incarceration – and the health of young adults in eight eastern European ...
Mark A Bellis, Karen Hughes, Nicola Leckenby, Lisa Jones, Adriana Baban, Margarita Kachaeva, Robertas Povilaitis, Iveta Pudule, Gentiana Qirjako, Betül Ulukol, Marija Raleva, Natasa Terzic   +11 more
doaj   +1 more source

Adverse Childhood Experiences (ACEs) in Pregnancy: Screening, Identification and Referral

, 2023
Adverse childhood experiences (ACEs) are traumatic events that occur between birth and eighteen years of age (Radcliffe, Crouch, & Strompolis, 2018). The ACEs questionnaire consists of ten “yes” or “no” questions that address abuse, neglect, parental
NC DOCKS at East Carolina University, Sells, Katherine   +1 more
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Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Positive childhood experiences are independently associated with adult resilience after accounting for adverse childhood experiences: A cross-sectional study in India

Acta Psychologica
Background: Adverse Childhood Experiences (ACEs) are known risk factors of poor adult mental health. Conversely, Positive Childhood Experiences (PCEs) have emerged as promotive factors associated with better mental health.
Gunjan Y. Trivedi, PhD
doaj   +1 more source

DISRUPTING THE CYCLE OF ACES: EXAMINING TEACHERS’ EXPERIENCES WITH SUPPORTING STUDENTS [PDF]

, 2023
Negative impacts to mental health and wellbeing that stem from exposure to adverse childhood experiences (ACEs) can contribute to high risk behaviours and health issues through a person’s lifetime.
Gorday, Lindsay
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Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Adverse childhood experiences (ACEs) : preventing early trauma to improve adult health [PDF]

Adverse Childhood Experiences (ACEs) are potentially traumatic events that occur in childhood. ACEs can include violence, abuse, and growingup in a family with mental health or substance use problems.

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Pedagogy and adverse childhood experiences : a teacher's action-learning journey in mitigating the impact of trauma through changing teaching practice

, 2020
School–university partnerships can be transformative for all involved; however, rarely are reports provided of the deep reciprocal changes that can occur as a result of this relationship.
Montgomery, Michelle (S32377), Parada, Roberto H. (R11618), Dobia, Brenda (R7599)   +2 more
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