Results 221 to 230 of about 592,211 (297)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

AI-driven pharmacovigilance: Enhancing adverse drug reaction detection with deep learning and NLP. [PDF]

MethodsX
Khemani DB, Malave DS, Shinde S, Shukla M, Shikalgar R, Talwar H.   +5 more
europepmc   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Adverse drug reaction reporting with the Med Safety app in Uganda: a cluster-randomised, controlled trial.

Lancet Glob Health
Kiguba R, Ndagije HB, Mwebaza N, Ssenyonga R, Giibwa L, Isabirye G, Owiny J, Nambasa V, Ntale I, Atuhaire J, Mwesigwa D, Mayengo J, Walusimbi D, Mugisa I, Katureebe C, Harrison K, Karamagi C, Pirmohamed M.   +17 more
europepmc   +1 more source

A computationally efficient biomedical text processing framework for pharmacovigilance: integrating low-rank adaptation and interpretable AI for adverse drug reaction detection. [PDF]

Med Biol Eng Comput
Rezaei Z, Samghabadi SS, Amini MA, Banad YM.   +3 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Artificial intelligence enabled audio-to-text transcription and translation for streamlined pharmacovigilance data collection and adverse drug reaction reporting. [PDF]

Perspect Clin Res
Hussain T, Mishra PS, Tiwari A, Parmar M, Gadaria S, Kannoj P.   +5 more
europepmc   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Spontaneous Adverse Drug Reaction Reporting of Congenital Malformations: A Danish National Register Study. [PDF]

Pharmaceuticals (Basel)
Lausten-Thomsen U, Olsen RH, Christiansen M, Hedley PL, Heerfordt IM, Andersen JT, Gade C.   +6 more
europepmc   +1 more source