Results 171 to 180 of about 976,952 (369)

GNTeam at 2018 n2c2: Feature-augmented BiLSTM-CRF for drug-related entity recognition in hospital discharge summaries [PDF]

arXiv, 2019
Monitoring the administration of drugs and adverse drug reactions are key parts of pharmacovigilance. In this paper, we explore the extraction of drug mentions and drug-related information (reason for taking a drug, route, frequency, dosage, strength, form, duration, and adverse events) from hospital discharge summaries through deep learning that ...
arxiv  

Multi-Task Pharmacovigilance Mining from Social Media Posts

, 2018
Social media has grown to be a crucial information source for pharmacovigilance studies where an increasing number of people post adverse reactions to medical drugs that are previously unreported.
Chowdhury, Shaika, Yu, Philip S., Zhang, Chenwei   +2 more
core   +1 more source

Spontaneous adverse drug reactions reported in a thirteen-year pharmacovigilance program in a tertiary university hospital

Frontiers in Pharmacology
ObjectivesWe aimed to assess the characteristics of adverse drug reactions (ADRs) collected in a university hospital.MethodsA retrospective analysis of ADRs spontaneously reported in the Hospital Pharmacovigilance Program database (RutiRAM) over a 13 ...
E. Montané, E. Montané, Y. Sanz, S. Martin, C. Pérez-Mañá, C. Pérez-Mañá, E. Papaseit, E. Papaseit, O. Hladun, G. De la Rosa, M. Farré, M. Farré   +11 more
doaj   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim, Ning Guo, Zong Yao Tan, Xing Gao, Pouria Fattahi, Haijiao Liu, Jeehan Chang, Mousa Younesi, Selice Jung, Yewhan Chung, Minkyung Song, Michelle Jung, Dan Dongeun Huh   +12 more
wiley   +1 more source

Evaluation of Adverse Drug Reaction (ADR) Monitoring and Reporting System in China [PDF]

Value in Health, 2014
F.J. Lin, R. Shao, X. Gao, J. Tang
openaire   +2 more sources

Causes of Drug-Induced Severe Cutaneous Adverse Reaction Epidermal Necrolysis (EN): An Analysis Using FDA Adverse Event Reporting System (FAERS) Database

, 2023
Weiqiang Fei, Jun Shen, Hui Cai
openalex   +2 more sources

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

Detecting adverse high-order drug interactions from individual case safety reports using computational statistics on disproportionality measures [PDF]

arXiv
Adverse drug interactions are a critical concern in pharmacovigilance, as both clinical trials and spontaneous reporting systems often lack the breadth to detect complex drug interactions. This study introduces a computational framework for adverse drug interaction detection, leveraging disproportionality analysis on individual case safety reports.
arxiv  

Signals of adverse reactions to anti-angiogenic drugs in cancer: a scoping review of the literature from studies of spontaneous reporting systems

, 2023
Valerio Ciccone, Marina Ziche, Andrea Spini, Sandra Donnini   +3 more
openalex   +1 more source