Results 111 to 120 of about 1,261,156 (366)

Evaluate the renal system damage caused by zoledronic acid: a comprehensive analysis of adverse events from FAERS

BMC Cancer
Background Zoledronic acid (ZA) is widely used for the treatment of osteolytic bone metastases in malignancies and osteoporosis, but it has been associated with renal impairment.
Zhaojun Wang, Xin Su, Donglei Shi, Li Wei   +3 more
doaj   +1 more source

Safety assessment of sapropterin dihydrochloride: real-world adverse event analysis based on the FDA adverse event reporting system (FAERS)

Frontiers in Pharmacology
ObjectiveSapropterin dihydrochloride is the first drug for the therapy of phenylketonuria, which is a rare disease that occurs one of 10,000–15,000 newborns.
Jiahong Zhong, Xihui Yu, Zhuomiao Lin
doaj   +1 more source

Retrofitting Vector Representations of Adverse Event Reporting Data to Structured Knowledge to Improve Pharmacovigilance Signal Detection [PDF]

arXiv, 2020
Adverse drug events (ADE) are prevalent and costly. Clinical trials are constrained in their ability to identify potential ADEs, motivating the development of spontaneous reporting systems for post-market surveillance. Statistical methods provide a convenient way to detect signals from these reports but have limitations in leveraging relationships ...
arxiv  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Data Mining in Large Frequency Tables With Ontology, with an Application to the Vaccine Adverse Event Reporting System [PDF]

arXiv, 2020
Vaccine safety is a concerning problem of the public, and many signal detecting methods have been developed to identify relative risks between vaccines and adverse events (AEs). Those methods usually focus on individual AEs, where the randomness of data is high. The results often turn out to be inaccurate and lack of clinical meaning.
arxiv  

Otorhinolaryngologic complications after COVID-19 vaccination, vaccine adverse event reporting system (VAERS)

Frontiers in Public Health
BackgroundThere have been reports of otolaryngological adverse event following immunization (AEFI) such as instances of olfactory and gustatory dysfunction following COVID-19 vaccination.
Jieun Shin, Jieun Shin, Sung Ryul Shim, Sung Ryul Shim, Jaekwang Lee, Hyon Shik Ryu, Jong-Yeup Kim, Jong-Yeup Kim, Jong-Yeup Kim   +8 more
doaj   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Adverse event profiles of CDK4/6 inhibitors: data mining and disproportionality analysis of the FDA adverse event reporting system

Therapeutic Advances in Drug Safety
Background: Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors are targeted therapies designed to selectively block CDK4/6, crucial regulators of the cell cycle.
Jun Shen, Pingli Luo, Jianmei Xu
doaj   +1 more source

Ophthalmic corticosteroids-related adverse events: the FDA adverse event reporting system (FAERS) database pharmacovigilance study

Frontiers in Pharmacology
BackgroundCorticosteroids are extensively used in ophthalmology, particularly for treating various inflammatory conditions. Despite their effectiveness, prolonged or high-dose corticosteroid use is associated with significant adverse drug reactions (ADRs)
Chengzhi Liu, Xinyu Wang, Xusheng Cao
doaj   +1 more source

Detect adverse drug reactions for drug Atorvastatin [PDF]

arXiv, 2013
Adverse drug reactions (ADRs) are big concern for public health. ADRs are one of most common causes to withdraw some drugs from markets. Now two major methods for detecting ADRs are spontaneous reporting system (SRS), and prescription event monitoring (PEM).
arxiv