Results 131 to 140 of about 476,894 (337)

A Real-World Disproportionality Analysis of Everolimus: Data Mining of the Public Version of FDA Adverse Event Reporting System [PDF]

Background: Everolimus is an inhibitor of the mammalian target of rapamycin and is used to treat various tumors. The presented study aimed to evaluate the Everolimus-associated adverse events (AEs) through data mining of the US Food and Drug ...
Chen, Xiangning, Cui, Shichao, Fu, Yumei, Liu, Shu, Luo, Lan, Zhao, Bin   +5 more
core   +1 more source

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

PIN1 VACCINE-ASSOCIATED GUILLAIN-BARRE SYNDROME: A PHARMACOVIGILANCE ANALYSIS OF DATA IN THE UNITED STATES' VACCINE ADVERSE EVENT REPORTING SYSTEM (1990-2009) [PDF]

, 2011
Ayad K. Ali
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Post-marketing drug safety surveillance of enfortumab vedotin: an observational pharmacovigilance study based on a real-world database

Frontiers in Immunology
BackgroundEnfortumab vedotin (EV) is an antibody-drug conjugate (ADC) that has been approved by the FDA for patients with locally advanced or metastatic urothelial carcinoma (UC). This study presents a comprehensive pharmacovigilance analysis of the post-
Mingming Yu, Lijun Zhou, Mengda Cao, Chunmei Ji, Yuanyi Zheng   +4 more
doaj   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Signal detection and analysis of adverse events associated with Genvoya® based the FAERS database

Frontiers in Pharmacology
ObjectiveThis study aims to evaluate and understand the safety profile of Genvoya® by mining and analyzing adverse drug event (ADE, adverse drug event) reports from the FDA Adverse Event Reporting System (FAERS, FDA Adverse Event Reporting System ...
Chengliang Wang, Yan Zhang, Xiting Tang, Guoping Zhang, Li Chen, Li Chen, Li Chen   +6 more
doaj   +1 more source

Patient safety in Europe: medication errors and hospital-acquired infections [PDF]

, 2008
The Report was commissioned by the European Federation of Nurses Associations (EFN) in November 2007 in order to support its policy statements on Patient Safety (June 2004).
Burke, J., Smith, L.N., Sveinsdóttir, H., Willman, A.   +3 more
core   +1 more source

Trans‐Conductive Melt Pool Scaling and its Implications for Parameter Transfer in Laser Powder Bed Fusion for Metals with High Thermal Diffusivity

Advanced Engineering Materials, EarlyView.
Developing process parameters for the laser‐based Powder Bed Fusion of metals can be a tedious task. Based on melt pool depth, the process parameters are transferable to different laser scan speeds. For this, understanding the melt pool scaling behavior is essential, particularly for materials with high thermal diffusivity, as a change in scaling ...
Markus Döring, Matthias Gehring, Michael Schmidt   +2 more
wiley   +1 more source