Background: Alpelisib was approved for treatment of breast cancer. We assessed the safety signals associated with alpelisib by data mining the FDA pharmacovigilance database. Methods: Data from the second quarter of 2019 to the fourth quarter of 2022 had
Yun Li, Hang Li, Zhongyuan Xiang
doaj
Text mining for the Vaccine Adverse Event Reporting System: medical text classification using informative feature selection [PDF]
Taxiarchis Botsis+4 more
openalex +1 more source
Adverse Event Profiles of Platinum Agents: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS, and Reproducibility of Clinical Observations [PDF]
Toshiyuki Sakaeda+2 more
openalex +1 more source
Heterozygous variants in AP4S1 are not associated with a neurological phenotype
Abstract Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function. We critically evaluate this claim against clinical observations in 28 heterozygous carriers of the same
Vicente Quiroz+9 more
wiley +1 more source
Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS [PDF]
Toshiyuki Sakaeda+6 more
openalex +1 more source
Targeted Long‐Read Sequencing as a Single Assay Improves the Diagnosis of Spastic‐Ataxia Disorders
ABSTRACT Objective The hereditary spastic‐ataxia spectrum disorders are a group of disabling neurological diseases. The traditional genetic testing pathway is complex, multistep and leaves many cases unsolved. We aim to streamline and improve this process using long‐read sequencing. Methods We developed a targeted long‐read sequencing strategy with the
Laura Ivete Rudaks+20 more
wiley +1 more source
Signal detection and analysis of adverse events associated with Genvoya® based the FAERS database
ObjectiveThis study aims to evaluate and understand the safety profile of Genvoya® by mining and analyzing adverse drug event (ADE, adverse drug event) reports from the FDA Adverse Event Reporting System (FAERS, FDA Adverse Event Reporting System ...
Chengliang Wang+6 more
doaj +1 more source
PIN1 VACCINE-ASSOCIATED GUILLAIN-BARRE SYNDROME: A PHARMACOVIGILANCE ANALYSIS OF DATA IN THE UNITED STATES' VACCINE ADVERSE EVENT REPORTING SYSTEM (1990-2009) [PDF]
A.K. Ali
openalex +1 more source
ABSTRACT Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease burden (prevalence and incidence).
Duan Ni+4 more
wiley +1 more source