Results 21 to 30 of about 476,894 (337)

Distributed Ledger Infrastructure to Verify Adverse Event Reporting (DeLIVER): Proposal for a Proof-of-Concept Study

JMIR Research Protocols, 2021
BackgroundAdverse drug event reporting is critical for ensuring patient safety; however, numbers of reports have been declining. There is a need for a more user-friendly reporting system and for a means of verifying reports that have been filed.
Milne-Ives, Madison, Lam, Ching, Rehman, Najib, Sharif, Raja, Meinert, Edward   +4 more
doaj   +1 more source

Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada. [PDF]

, 2015
This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia.
Abagyan, Ruben, Ali, Thibault B, Chen, Winston Yuchen, Reilly, Brian M, Schleret, Thomas R   +4 more
core   +3 more sources

Methods for Detecting and Measuring Adverse Hospital Events [PDF]

Iranian Journal of Public Health, 2005
Introduction: An adverse event is defined as an unexpected event such as a patient fall, a drug reaction or an infection, which leads to patient injury and is caused by healthcare management rather than patient own diseases.
A Baba-Akbari Sari, TA Sheldon
doaj   +2 more sources

Publicity and reports of behavioral addictions associated with dopamine agonists [PDF]

, 2015
Background The development of behavioral addictions (BAs) in association with dopamine agonists (DAs, commonly used to treat Parkinson’s disease) has been reported.
Gendreau, Katherine E., Potenza, Marc N.
core   +1 more source

Assessment of Reye’s syndrome profile with data from the US Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report databases using the disproportionality analysis

SAGE Open Medicine, 2020
Objectives: Reye’s syndrome is a rare and potentially fatal illness that is defined as encephalopathy accompanied by liver failure. The aim of this study was to assess Reye’s syndrome profiles by analyzing data from the spontaneous reporting system ...
Kiyoka Matsumoto, Shiori Hasegawa, Satoshi Nakao, Kazuyo Shimada, Ririka Mukai, Mizuki Tanaka, Riko Satake, Yu Yoshida, Fumiya Goto, Misaki Inoue, Hiroaki Ikesue, Kazuhiro Iguchi, Tohru Hashida, Mitsuhiro Nakamura   +13 more
doaj   +1 more source

Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database [PDF]

, 2013
Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US ...
A Bate, A Clarke, A Pariente, AK Chung, Ariola Koci, B Darpo, BJ Drew, C Meyer-Massetti, DM Roden, DW Hough, E Poluzzi, E Poluzzi, E Poluzzi, E Raschi, E Raschi, Edoardo Spina, Elijah R. Behr, Elisabetta Poluzzi, Emanuel Raschi, EP Puijenbroek van, ER Behr, F Ponti De, F Ponti De, F Rani, Fabrizio De Ponti, GC Alexander, GK Isbister, H Verdoux, J Nielsen, J Papay, K Jolly, K Titier, LC Wittkampf, LS Schneider, Miriam Sturkenboom, NP Tatonetti, P Kannankeril, P Manu, P Vigneault, RC Owens Jr, RR Shah, S Dhillon, S Hennessy, S Kongsamut, S Leucht, SM Straus, Ugo Moretti, W Crumb, W Crumb, WA Ray, WA Ray, WJ Crumb Jr, WP Stephenson, Y Suzuki   +53 more
core   +3 more sources

Simulating adverse event spontaneous reporting systems as preferential attachment networks [PDF]

Applied Clinical Informatics, 2014
Summary Background: Spontaneous Reporting Systems [SRS] are critical tools in the post-licensure evaluation of medical product safety. Regulatory authorities use a variety of data mining techniques to detect potential safety signals in SRS databases.
Robert Ball, Taxiarchis Botsis, John Scott   +2 more
openaire   +3 more sources

Serious Cardiovascular Adverse Events Reported with Intravenous Sedatives: A Retrospective Analysis of the MedWatch Adverse Event Reporting System [PDF]

Drugs - Real World Outcomes, 2019
Serious cardiovascular adverse events (SCAEs) associated with intravenous sedatives remain poorly characterized.The objective of this study was to compare SCAE incidence, types, and mortality between intravenous benzodiazepines (i.e., diazepam, lorazepam, and midazolam), dexmedetomidine, and propofol in the USA over 8 years regardless of the clinical ...
Jonathan Weinstock, Mo Dimbil, Nick O'Donnell, Christopher Madias, Keith B. Hoffman, Matthew S. Duprey, Nada S. Al-Qadheeb, John W. Devlin, John W. Devlin   +8 more
openaire   +3 more sources

Adverse drug event reporting systems: a systematic review [PDF]

British Journal of Clinical Pharmacology, 2016
AimAdverse drug events (ADEs) are harmful and unintended consequences of medications. Their reporting is essential for drug safety monitoring and research, but it has not been standardized internationally. Our aim was to synthesize information about the type and variety of data collected within ADE reporting systems.MethodsWe developed a systematic ...
David Peddie, David Peddie, Maeve E. Wickham, Maeve E. Wickham, Ellen Balka, Ellen Balka, Mary M. Doyle-Waters, Katherin Badke, Katherin Badke, Chantelle Bailey, Chantelle Bailey, Corinne M. Hohl, Corinne M. Hohl, Serena S Small, Serena S Small   +14 more
openaire   +2 more sources

A real-world disproportionality analysis of apalutamide: data mining of the FDA adverse event reporting system

Frontiers in Pharmacology, 2023
Background: Apalutamide is a new drug class, which is approved to treat prostate cancer (PCa). The aim of our study was to assess the safety profiles of apalutamide in real-world through data mining of the United States Food and Drug Administration ...
Zhihong Fang, Zhiqiang Xu, Wei Zhu, Mingming Yu, Chunmei Ji   +4 more
doaj   +1 more source