Results 251 to 260 of about 1,340,339 (303)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim, Woochan Kim, Harshita Sharma, Shinyull Lee, Chaeyeon Park, Sunho Park, Chan Yeong Heo, Jangho Kim   +7 more
wiley   +1 more source

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source

Poly(hydroxy‐oxazolidone) Thermoplastic Elastomers for Safer, Greener and Customizable Blood‐Contacting Medical Devices

Advanced Healthcare Materials, EarlyView.
A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo, Anna Pierrard, Fréderic Lifrange, Marco Caliari, Céline D'Emal, Margaux Debuisson, Haritz Sardon, Philippe Delvenne, Patrizio Lancellotti, Christophe Detrembleur, Christine Jérôme, Cécile Oury   +11 more
wiley   +1 more source

Biomimetic Scaffolds with Dual Gradients of Biological Effectors for Tendon‐to‐Bone Repair

Advanced Healthcare Materials, EarlyView.
The authors have developed a biomimetic scaffold with dual gradients through a diffusion‐driven method. The scaffold features funnel‐shaped microchannels for cell infiltration, while the dual gradients synergetically induce the graded differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and tenocytes, allowing for a seamless ...
Min Hao, Yidan Chen, Stavros Thomopoulos, Younan Xia   +3 more
wiley   +1 more source

Adverse events of pancreatic fluid collections

VideoGIE, 2018
Judith E. Baars, MD, PhD, Arthur J. Kaffes, MBBS, FRACP, Payal Saxena, MBBS, FRACP   +2 more
doaj  

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Adverse Events and Preventable Adverse Events in Children

Pediatrics, 2005
Context. Patient safety has been recognized as an important problem in health care. However, knowledge about adverse events and preventable adverse events in children is relatively limited. Objective. To describe the incidence and types of adverse events and preventable adverse events in children. Design.
Stuart H. Altman, Jane L. Holl, Eric J. Thomas, Troy Brennan, Donna M. Woods   +4 more
openaire   +3 more sources

Reduction of Adverse Events

Pediatrics In Review, 2020
1. Leslie J. Davis, DO*,† 2. David A. Wathen, DO*,† 1. *Saint Louis University School of Medicine, St Louis, MO 2. †SSM Health Cardinal Glennon Children’s Hospital, St Louis, MO For those who work in health-care, it is not difficult to think of examples from our careers where patient safety has been compromised, whether that be a near-miss ...
Leslie J. Davis, Leslie J. Davis, David Wathen, David Wathen   +3 more
openaire   +3 more sources

Adverse events of PARP inhibitors

Česká gynekologie, 2021
An evaluation of the safety of poly-ADP-ribose-polymerase inhibitors (PARPi) in ovarian cancer treatment.An analysis of the studies on PARP inhibitors, a summary of the most common and serious adverse events.According to the studies, the most common adverse events of PARPi include hematotoxicity, nausea and vomiting.
Jaroslav Klát, Martina Romanová
openaire   +3 more sources

Hepatobiliary Adverse Events

2020
Immune checkpoint inhibitors (ICIs) are increasingly used for multiple cancer types. Hepatotoxicity is a reported adverse event of ICI treatment. It can present as asymptomatic elevation of aspartate transaminase and alanine transaminase or symptomatic hepatitis with fever, malaise, and even death in rare cases.
Hamzah Abu-Sbeih, Yinghong Wang
openaire   +3 more sources