Survival analysis for AdVerse events with VarYing follow-up times (SAVVY): Rationale and statistical concept of a meta-analytic study [PDF]
Biom. J., 2021, 63, 650-670, 2019 The assessment of safety is an important aspect of the evaluation of new therapies in clinical trials, with analyses of adverse events being an essential part of this. Standard methods for the analysis of adverse events such as the incidence proportion, i.e.
arxiv +1 more source
A Sui Generis QA Approach using RoBERTa for Adverse Drug Event Identification [PDF]
BMC Bioinformatics 22, 330 (2021), 2020 Extraction of adverse drug events from biomedical literature and other textual data is an important component to monitor drug-safety and this has attracted attention of many researchers in healthcare. Existing works are more pivoted around entity-relation extraction using bidirectional long short term memory networks (Bi-LSTM) which does not attain the
arxiv +1 more source
The Rise of Patient Safety-II: Should We Give Up Hope on Safety-I and Extracting Value From Patient Safety Incidents?; Comment on “False Dawns and New Horizons in Patient Safety Research and Practice” [PDF]
International Journal of Health Policy and Management, 2018 Who could disagree with the seemingly common-sense reasoning that: “We must learn from the things that go wrong.”? Despite major investments to improve patient safety, relatively few evaluations demonstrate convincing reductions in risk, harm, serious ...
Andrew Carson-Stevens +2 more
doaj +1 more source
Perspectives in Clinical Research, 2022 Background: Medical faculty and residents have a key role in the reporting of adverse events associated with medical devices. However, at present, there are no published data regarding their knowledge, attitude, and practice about materiovigilance in ...
Bikash Ranjan Meher +3 more
doaj +1 more source
Serious Neurological Adverse Events of Ceftriaxone
Antibiotics, 2021 We described ceftriaxone-induced CNS adverse events through the largest case series of Adverse Drug Reactions (ADRs) reports, from 1995 to 2017, using the French Pharmacovigilance Database.
Clémence Lacroix +5 more
doaj +1 more source
Boosting Adverse Drug Event Normalization on Social Media: General-Purpose Model Initialization and Biomedical Semantic Text Similarity Benefit Zero-Shot Linking in Informal Contexts [PDF]
arXiv, 2023 Biomedical entity linking, also known as biomedical concept normalization, has recently witnessed the rise to prominence of zero-shot contrastive models. However, the pre-training material used for these models has, until now, largely consisted of specialist biomedical content such as MIMIC-III clinical notes (Johnson et al., 2016) and PubMed papers ...
arxiv
Neurologic adverse events of cancer immunotherapy
Arquivos de Neuro-Psiquiatria, 2022 Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers.
Marcelo Houat de Brito
doaj +1 more source
DS4DH at #SMM4H 2023: Zero-Shot Adverse Drug Events Normalization using Sentence Transformers and Reciprocal-Rank Fusion [PDF]
arXiv, 2023 This paper outlines the performance evaluation of a system for adverse drug event normalization, developed by the Data Science for Digital Health (DS4DH) group for the Social Media Mining for Health Applications (SMM4H) 2023 shared task 5. Shared task 5 targeted the normalization of adverse drug event mentions in Twitter to standard concepts of the ...
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source