Results 131 to 140 of about 278,304 (313)

Nationwide Temporal Trends in Adverse Pregnancy Outcomes and Treatments in Systemic Lupus Erythematosus Pregnancy Over Two Decades in Sweden

Arthritis &Rheumatology, EarlyView.
Objective This nationwide descriptive study examined temporal trends in adverse pregnancy outcomes (APOs) and treatments in systemic lupus erythematosus (SLE) pregnancies in Sweden over 2003 to 2022. Methods Using nationwide Swedish registers, we identified 1,417 pregnancies of women with prevalent SLE and delivery dates in 2003 to 2022 and matched ...
Ngoc V. Nguyen, Anna Sandström, Annica Dominicus, Elisabet Svenungsson, Karin Hellgren, Julia F. Simard, Elizabeth V. Arkema   +6 more
wiley   +1 more source

Maternal Periodontitis, Preeclampsia and Adverse Pregnancy Outcomes

Journal of Midwifery & Reproductive Health, 2013
Background and Aim: Preeclampsia is a considerable problem of pregnancy. Endothelial dysfunction and placental hypoxia are the current hypothesis of preeclampsia. Chronic inflammation, including periodontitis may provoke systemic maternal and placental pro-inflammatory endothelial dysfunction, which represent a significant risk factor for diseases of ...
Afshari, Pourandokht, Sheinizadeh, Shaghayegh, Rangbari, Ardeshir, khalilinejad, Foroogh   +3 more
openaire   +2 more sources

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

A multicountry randomized controlled trial of comprehensive maternal nutrition supplementation initiated before conception: the Women First trial. [PDF]

, 2019
Background: Reported benefits of maternal nutrition supplements commenced during pregnancy in low-resource populations have typically been quite limited.
Ali, Sumera A., Bauserman, Melissa, Bose, Carl L., Das, Abhik, Derman, Richard J., Dhaded, Sangappa M., Figueroa, Lester, Garcés, Ana, Goldenberg, Robert L., Goudar, Shivaprasad S., Hambidge, K. Michael, Koso-Thomas, Marion, Krebs, Nancy F., Lokangaka, Adrien, McClure, Elizabeth M., Pasha, Omrana, Sridhar, Amaanti, Stolka, Kristen, Thorsten, Vanessa R., Tshefu, Antoinette, Westcott, Jamie E.   +20 more
core   +1 more source

Setting up mother–infant pair lactation studies with biobanking for research according to regulatory requirements

British Journal of Clinical Pharmacology, EarlyView.
Within the ConcePTION project we set out to design two mother–infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding.
Mats Hansson, Ida Björkgren, Jenny Svedenkrans, Helena Backman, Jarl Hellman, Linda Englund‐Ögge, Mikaela Magnusson, Inger Lindström, Andrea Wutte, Erica Sundell, Pawel Baranczewski, Laura Shaughnessy   +11 more
wiley   +1 more source

Adverse birth outcomes in United Republic of Tanzania: impact and prevention of maternal risk factors

Bulletin of the World Health Organization
OBJECTIVE: To determine risk factors for poor birth outcome and their population attributable fractions. METHODS: 1688 women who attended for antenatal care were recruited into a prospective study of the effectiveness of syphilis screening and treatment.
Deborah Watson-Jones, Helen A Weiss, John M Changalucha, James Todd, Balthazar Gumodoka, Judith Bulmer, Rebecca Balira, David Ross, Kokungoza Mugeye, Richard Hayes, David Mabey   +10 more
doaj   +1 more source

The impact of Sure Start local programmes on three-year-olds and their families [PDF]

, 2008
This evaluation found that living in a Sure Start Local Programme (SSLP) area was associated with positive impacts on 5 of the 14 outcomes investigated.
Belsky, Jay, Leyland, A.H., Melhuish, Edward C.   +2 more
core  

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Shock Index in the Prediction of Adverse Maternal Outcome. [PDF]

J Obstet Gynaecol India, 2020
Chaudhary M, Maitra N, Sheth T, Vaishnav P.   +3 more
europepmc   +1 more source