Results 61 to 70 of about 2,016,996 (294)

Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease [PDF]

, 2014
Background Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions.
Angelberger, Angelberger, Ardizzone, Armuzzi, Armuzzi, Armuzzi, Benchimol, Bernell, Colonna, D'Haens, D'Haens, Dilger, Doherty, Ferrante, Gordon, Guyatt, Hafraoui, Hanauer, Hanauer, Herfarth, Herfarth, Higgins, Higgins, Korelitz, Manosa, Mañosa, Nos, Pitkin, Prefontaine, Regueiro, Reinisch, Reinisch, Reinisch, Reinisch, Rolfe, Rutgeerts, Savarino, Savarino, Savarino, Schünemann, Steinhart, Williams   +41 more
core   +1 more source

Bioenergetics-adverse outcome pathway: Linking organismal and suborganismal energetic endpoints to adverse outcomes [PDF]

Environmental Toxicology and Chemistry, 2018
Abstract Adverse outcome pathways (AOPs) link toxicity across levels of biological organization, and thereby facilitate the development of suborganismal responses predictive of whole-organism toxicity and provide the mechanistic information necessary for science-based extrapolation to population-level effects.
Christopher G, Goodchild, Adam M, Simpson, Matteo, Minghetti, Sarah E, DuRant   +3 more
openaire   +2 more sources

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Course of neuromyelitis optica during inadvertent pregnancy in a patient treated with rituximab [PDF]

, 2009
In neuromyelitis optica (NMO), the monoclonal B-cell antibody rituximab is a therapeutic option. Little is known about the course of NMO and the safety of rituximab during pregnancy.
Hohlfeld, R., Kümpfel, Tania, Pellkofer, H. L., Schulze, A., Suessmair, C.   +4 more
core   +1 more source

Adverse outcome pathways: opportunities, limitations and open questions [PDF]

Archives of Toxicology, 2017
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event relationships (KER)
Leist, Marcel, Ghallab, Ahmed, Graepel, Rabea, Marchan, Rosemarie, Hassan, Reham, Bennekou, Susanne Hougaard, Limonciel, Alice, Vinken, Mathieu, Schildknecht, Stefan, Waldmann, Tanja, Danen, Erik, van Ravenzwaay, Ben, Kamp, Hennicke, Gardner, Iain, Godoy, Patricio, Bois, Frédéric, Braeuning, Albert, Reif, Raymond, Oesch, Franz, Drasdo, Dirk, Höhme, Stefan, Schwarz, Michael, Hartung, Thomas, Braunbeck, Thomas, Beltman, Joost, Vrieling, Harry, Sanz, Ferran, Forsby, Anna, Gadaleta, Domenico, Fisher, Ciarán, Kelm, Jens, Fluri, David, Ecker, Gerhard, Zdrazil, Barbara, Terron, Andrea, Jennings, Paul, van Der Burg, Bart, Dooley, Steven, Meijer, Annemarie, Willighagen, Egon, Martens, Marvin, Evelo, Chris, Mombelli, Enrico, Taboureau, Olivier, Mantovani, Albert, Hardy, Barry, Koch, Bjorn, Escher, Sylvia, van Thriel, Chris, Cadenas, Cristina, Kroese, Dinant, van de Water, Bob, Hengstler, Jan   +52 more
openaire   +6 more sources

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Obstetric emergencies and adverse maternal-perinatal outcomes in Ethiopia; A systematic review and meta-analysis

Frontiers in Global Women's Health, 2022
BackgroundObstetric emergencies are life-threatening medical problems that develop during pregnancy, labor, or delivery. There are a number of pregnancy-related illnesses and disorders that can endanger both the mother's and the child's health.
Masresha Leta, Nega Assefa, Maleda Tefera   +2 more
doaj   +1 more source

Is antenatal syphilis screening still cost effective in sub-Saharan Africa [PDF]

, 2003
Objectives: To estimate the cost effectiveness of on-site antenatal syphilis screening and treatment in\ud Mwanza, Tanzania. To compare this intervention with other antenatal and child health interventions,\ud specifically the prevention of mother to ...
Changalucha, J, Gumodoka, B, Hays, R, Kumaranayake, L, Lisekie, F, Mabey, D, Mugeye, K, Ndeli, L, Terris-Prestholt, F, Todd, J, Watson-Jones, D, Weiss, H   +11 more
core   +2 more sources

Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]

, 2020
Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Brighton, Paul (Paul J.), Brosens, Jan J., Da Costa, Maria José Minhoto Diniz, Ewington, Lauren J., Fishwick, Katherine, Fujihara, Risa, Kimani, Peter K., Lacey, Lauren, Lucas, Emma S., Muter, Joanne, Polanco, Angela, Quenby, Siobhan, Takeda, Satoru, Tewary, Shreeya   +13 more
core   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source