Results 31 to 40 of about 76,101 (196)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Role of the cerebroplacental ratio and non-stress test in predicting adverse perinatal outcomes in high-risk pregnancies

The Journal of Maternal-Fetal & Neonatal Medicine
Objective High-risk pregnancies are associated with increased risk of fetal and maternal morbidity and mortality. The non-stress test (NST) is the standard method for antenatal fetal monitoring, while the cerebroplacental ratio (CPR) has emerged as a ...
Hoang Trang Nguyen Thi, Ngoc Ha Nguyen Thi, Tam Vu Van, Quoc Huy Nguyen Vu   +3 more
doaj   +1 more source

Brain Health for Children

Brain Health, EarlyView.
ABSTRACT The World Health Organization (WHO) defines brain health as the maintenance of optimal brain integrity, good mental state, and cognitive function without significant neuropsychiatric disease. Early childhood is a critical period for brain development, which were influenced by early experiences, nutrition, and environmental factors. Disruptions
Yu Ma, Wenjuan Ma, Yue Jiang, Weiyi Chen, Yuanfeng Zhou, Yi Wang   +5 more
wiley   +1 more source

Association between hyperuricemia and adverse perinatal outcomes among women with preeclampsia at a tertiary hospital in Southwestern Uganda: a prospective cohort study

The Journal of Maternal-Fetal & Neonatal Medicine
Background Pre-eclampsia is a major cause of adverse perinatal outcomes, such as preterm birth and perinatal deaths, at Mbarara Regional Referral Hospital (MRRH).
Hani Omar Wehlie, Yarine Fajardo Tornes, Julius Businge, Onesmus Byamukama, Musa Kayondo, Paul Kato Kalyebara, Joseph Ngonzi, Henry Mark Lugobe, Brenda Ainomugisha, Leevan Tibaijuka   +9 more
doaj   +1 more source

Effect of Preterm Birth on the Risk of Adverse Perinatal and Neonatal Outcomes in Ethiopia: A Systematic Review and Meta-Analysis

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2021
Despite remarkable progress in the reduction of under-five mortality, the rate of perinatal and neonatal mortality is still high especially in developing countries.
Melaku Desta MSc, Melaku Admas MSc, Yordanos Yeshitila MSc, Belsity Meselu MSc, Keralem Bishaw MSc, Moges Assemie MSc, Nigus Yimer MSc, Getachew Kassa PhD   +7 more
doaj   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Freedon study: Real‐life outcomes of cenobamate in different lines of treatment

Epilepsia, EarlyView.
Abstract Objectives Cenobamate is an antiseizure medication (ASM) with proven effectiveness in individuals with highly refractory epilepsy. This study investigated the effectiveness and tolerability of cenobamate in different treatment lines and a less refractory setting. Methods This was a multicenter, retrospective, observational study.
Vicente Villanueva, José María Serratosa, Alejandro Fernández‐Cabrera, Manuel Toledo, Beatriz González‐Giráldez, José C. Estevez, Juan Jesús Rodríguez Uranga, Maria Machio Castelló, Maria Dolores Castro‐Vilanova, Juan José Poza, Xiana Rodríguez‐Osorio, Kevin G. Hampel, Elena Fonseca, Francisco Javier López‐González, Mercedes Garcés, Laura Abraira, Jordi Ciurans, Daniel Campos‐Fernández, Estevo Santamarina, Juan María Sanchez‐Caro, Lucas Iacampo, Julia Renau, Miguel Ángel García‐Quesada, Carla Anciones, María Isabel Chamorro, Iratxe Maestro, Pablo Cabezudo, Raquel Calle, Jesús Macarron, Beatriz Cabezas, María Carrasco, María López, Marta Marín, Rosa Querol, Belén Baena, Vanessa García‐Morales, Samuel López‐Maza, Álvaro Juiz, Blanca Mercedes‐Alvarez, Carla Amarante, Ana del Villar, Ascensión Castillo, Marta Rubio‐Roy, Javier Martinez‐Poles, Asier Gómez‐Ibáñez, Beatriz Parejo‐Carbonell, Anabelén Martínez Garcia, Ignacio Carrera, Pablo Iriarte, Fátima Romero‐Aguilera, on behalf of the Pharmacological Therapy Working group of the Spanish Epilepsy Society and Freedon Group   +50 more
wiley   +1 more source

Did the French pregnancy pictogram change antiseizure medication use during pregnancy?

Epilepsia, EarlyView.
Abstract Objective The aim of this study was to assess the impact of introducing a pregnancy pictogram on medication packaging on the prescription and dispensation of antiseizure medications and on the maternal and neonatal outcomes for women exposed to these medications.
Mélanie Araujo, Christine Damase‐Michel, Marie Denuelle, Sébastien Boulogne, Laurane Delteil, Monica Saucedo, Catherine Deneux‐Tharaux, Isabelle Lacroix   +7 more
wiley   +1 more source

Maternal near miss as a predictor of adverse perinatal outcomes: findings from a prospective cohort study in southwestern Uganda

BMC Pregnancy and Childbirth
Background Despite efforts, Uganda has not met the World Health Organization target of
Mark Jjuuko, Henry Mark Lugobe, Richard Migisha, David Collins Agaba, Leevan Tibaijuka, Musa Kayondo, Joseph Ngonzi, Paul Kato Kalyebara, Hamson Kanyesigye   +8 more
doaj   +1 more source

Perinatal outcomes of women with hypertensive disorders of pregnancy in Jimma Medical Center, southwest Ethiopia: Retrospective cohort study.

PLoS ONE, 2021
BackgroundHypertensive disorders of pregnancy (HDP) increases adverse perinatal outcomes in women with the disorder. About 16% of all still births and 10% of early neonatal deaths are accounted by HDP.
Debela Dereje Jaleta, Tadesse Gebremedhin, Mulusew Gerbaba Jebena   +2 more
doaj   +1 more source