Results 31 to 40 of about 84,712 (215)

Adverse perinatal outcomes attributable to HIV in sub-Saharan Africa from 1990 to 2020: Systematic review and meta-analyses

Communications Medicine, 2023
Background Maternal HIV infection and antiretroviral drugs (ARVs) are associated with increased risks of adverse perinatal outcomes. The vast majority of pregnant women living with HIV (WLHIV) reside in sub-Saharan Africa.
Claudia Murray, Clara Portwood, Harriet Sexton, Mary Kumarendran, Zoe Brandon, Shona Kirtley, Joris Hemelaar   +6 more
doaj   +1 more source

The burden of severe hypertensive disorders of pregnancy on perinatal outcomes: a nationwide case-control study in SurinameAJOG Global Reports at a Glance

AJOG Global Reports, 2021
BACKGROUND: Latin America and the Caribbean is the region with the highest prevalence of hypertensive disorders of pregnancy worldwide. In Suriname, where the stillbirth rate is the second highest in the region, it is not yet known which maternal factors
Zita D. Prüst, MD, Lachmi R. Kodan, MD, PhD, MSc, Thomas van den Akker, MD, PhD, Kitty W.M. Bloemenkamp, MD, PhD, Marcus J. Rijken, MD, PhD, Kim J.C. Verschueren, MD, PhD   +5 more
doaj   +1 more source

The “costly son” hypothesis: Sons exacerbate obstetrical dilemmas in humans and other mammals

The Anatomical Record, EarlyView.
Abstract Human childbirth has often been considered uniquely difficult among mammals, yet recent evidence suggests that obstructed labor and fetopelvic disproportion are widespread across placental mammals. Here, we propose the “costly son” hypothesis: because male offspring are typically larger at birth, they impose greater obstetric risk on mothers ...
Nicole D. S. Grunstra, Jonathan C. K. Wells   +1 more
wiley   +1 more source

Role of the cerebroplacental ratio and non-stress test in predicting adverse perinatal outcomes in high-risk pregnancies

The Journal of Maternal-Fetal & Neonatal Medicine
Objective High-risk pregnancies are associated with increased risk of fetal and maternal morbidity and mortality. The non-stress test (NST) is the standard method for antenatal fetal monitoring, while the cerebroplacental ratio (CPR) has emerged as a ...
Hoang Trang Nguyen Thi, Ngoc Ha Nguyen Thi, Tam Vu Van, Quoc Huy Nguyen Vu   +3 more
doaj   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Association between hyperuricemia and adverse perinatal outcomes among women with preeclampsia at a tertiary hospital in Southwestern Uganda: a prospective cohort study

The Journal of Maternal-Fetal & Neonatal Medicine
Background Pre-eclampsia is a major cause of adverse perinatal outcomes, such as preterm birth and perinatal deaths, at Mbarara Regional Referral Hospital (MRRH).
Hani Omar Wehlie, Yarine Fajardo Tornes, Julius Businge, Onesmus Byamukama, Musa Kayondo, Paul Kato Kalyebara, Joseph Ngonzi, Henry Mark Lugobe, Brenda Ainomugisha, Leevan Tibaijuka   +9 more
doaj   +1 more source

Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation

Autism Research, EarlyView.
ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD).
Michelle Pearl, Kimberly Berger, Piera M. Cirillo, Nickilou Y. Krigbaum, Victor Poon, Gayle C. Windham, Barbara A. Cohn   +6 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Effect of Preterm Birth on the Risk of Adverse Perinatal and Neonatal Outcomes in Ethiopia: A Systematic Review and Meta-Analysis

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2021
Despite remarkable progress in the reduction of under-five mortality, the rate of perinatal and neonatal mortality is still high especially in developing countries.
Melaku Desta MSc, Melaku Admas MSc, Yordanos Yeshitila MSc, Belsity Meselu MSc, Keralem Bishaw MSc, Moges Assemie MSc, Nigus Yimer MSc, Getachew Kassa PhD   +7 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source