Results 91 to 100 of about 187,960 (311)

Preconception care for diabetic women for improving maternal and fetal outcomes : a systematic review and meta-analysis [PDF]

, 2010
Background Preexisting diabetes mellitus is associated with increased risk for maternal and fetal adverse outcomes. Despite improvement in the access and quality of antenatal care recent population based studies demonstrating increased congenital ...
Ghada A Bawazeer, Alansari, Lubna A., Rasmeia A Alzeidan, Samia A Esmaeil, Wahabi, Haifa A. A., Lubna A Alansari, Wahabi, Hayfaa A., Alzeidan, Rasmeia A., Alzeidan, Rasmieh A., Hayfaa A Wahabi, Bawazeer, Ghada A., Esmaeil, Samia A.   +11 more
core   +1 more source

Estimated effect of teenage pregnancy on adverse birth outcome in Sub-Saharan African countries: propensity score matching analysis of recent demographic and health survey data

BMC Pregnancy and Childbirth
Introduction Globally adverse birth outcome is being a series public health problem. As studies showed, even though the etiologies are multifactorial, extreme age pregnancies have more risk for adverse birth outcome.
Getachew Teshale, Endalkachew Dellie, Andualem Yalew Aschalew, Chalie Tadie Tsehay, Nigusu Worku, Tesfahun Zemene Tafere, Nebebe Demis Baykemagn, Asebe Hagos   +7 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Influence of Short Birth Spacing on Pregnancy Outcome

, 2003
This descriptive study was carried out to determine the effect of short birth interval (4years, while short birth interval (
Hamid, Fatima
core  

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring [PDF]

, 2009
Background Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology. Aims To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring ...
David Gunnell, Dieter Wolke, Jeremy Horwood, Kate Thomas, Andrew Thompson, Gunnell, David, Lewis, Glyn, Harrison, Glynn, Stanley Zammit, Paulo Menezes, Hollis, Chris, Glyn Lewis, Wolke, Dieter, Zammit, Stanley, Horwood, Jeremy, Thomas, Kate, Thompson, Andrew D., Menezes, Paulo, Chris Hollis, Glynn Harrison, Thompson, Andrew   +20 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Antiretroviral therapy and pregnancy outcome in HIV-infected women in the United Kingdom and Ireland [PDF]

, 2009
The aim of this thesis is to explore pregnancy and perinatal outcomes in diagnosed HIV-infected women receiving antiretroviral therapy (ART) in the UK (United Kingdom) and Ireland.
Townsend, C L, Townsend, C.L.
core  

Preterm birth and small for gestational age in relation to alcohol consumption during pregnancy: stronger associations among vulnerable women? Results from two large Western-European studies

, 2013
Pfinder M, Kunst AE, Feldmann R, van Eijsden M, Vrijkotte TGM. Preterm birth and small for gestational age in relation to alcohol consumption during pregnancy: stronger associations among vulnerable women? Results from two large Western-European studies.
van Eijsden, M., Feldmann, R., Kunst, A.E., Kunst, Anton E, van Eijsden, Manon, Tanja G M Vrijkotte, Anton E Kunst, Feldmann, Reinhold, Kunst, Anton E., Vrijkotte, Tanja G. M., Reinhold Feldmann, Pfinder, Manuela, Pfinder, M., Vrijkotte, T.G.M., Manuela Pfinder, Manon van Eijsden   +15 more
core   +1 more source