Results 111 to 120 of about 933,218 (307)
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source
Journal of the American College of Cardiology, 2019 Adverse pregnancy outcomes (APOs)-including pre-term birth, pre-eclampsia, and intrauterine growth restriction-are common interrelated disorders caused by placental dysfunction and maternal vascular abnormalities (endothelial activation, inflammation ...
A. Lane-Cordova +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes +15 more
wiley +1 more source
Journal of Indian Academy of Oral Medicine and RadiologyBackground: Research indicates that the poor oral hygiene can increase the risk of developing adverse pregnancy outcomes, such as preterm birth, low birth weight, and preeclampsia. However, the results are long debated.
Prashanth Shenoy +5 more
doaj +1 more source
The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton
Advanced Science, EarlyView.Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang +32 more
wiley +1 more source
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
GESTATIONAL DIABETES MELLITUS (BASED ON THE RESULTS OF A SCREENING STUDY IN THE MOSCOW REGION)
Alʹmanah Kliničeskoj Mediciny, 2016 Background: New diagnostic criteria for gestational diabetes mellitus (GDM) are being currently implemented into clinical practice. GDM prevalence and pregnancy outcomes in women with GDM diagnosed according to the new criteria have not been studied in ...
A. V. Dreval' +2 more
doaj +1 more source
Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study
BMC Pregnancy and Childbirth, 2019 BackgroundThe increased potential for negative pregnancy outcomes in both extremes of reproductive age is a well-debated argument. The aim of this study was to analyze the prevalence and the outcome of pregnancies conceived at extreme maternal ages ...
A. Londero +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
THE PREVALENCE OF EXTRAGENITAL RISK FACTORS AND THEIR IMPACT ON ADVERSE PREGNANCY OUTCOMES
Siberian Journal of Life Sciences and Agriculture, 2019 Background. To study the prevalence of extragenital factors and their impact on the risk of adverse pregnancy outcomes in the Krasnoyarsk region. Materials and methods. The data of perinatal monitoring of the Krasnoyarsk territory, which operates on the
Renat Badrudinovich Kurbanismailov +3 more
doaj +1 more source