Results 191 to 200 of about 1,057,698 (355)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells

Advanced Science, EarlyView.
In this study, it is shown that 1‐day co‐culture with activated T cells or IL‐2‐presenting synthetic cells significantly enhances NK cell motility and cytotoxicity in 2D and 3D. Notably, synthetic cells restore the impaired cytotoxic function of cryopreserved NK and CAR‐NK cells in 3D.
Xiangda Zhou, Sijia Zhang, Wenjuan Yang, Susanne Gonder, Zeinab Sadjadi, Nils Piernitzki, Alina Moter, Shulagna Sharma, Anne Largeot, Nadja Küchler, Lea Kaschek, Gertrud Schäfer, Eva C. Schwarz, Hermann Eichler, Evelyn Ullrich, Heiko Rieger, Oskar Staufer, Jérôme Paggetti, Etienne Moussay, Markus Hoth, Bin Qu   +20 more
wiley   +1 more source

National Advisory Committee on Research in the Geological Sciences, twelfth annual report, 1961-62 (including survey of current research in the geological sciences in Canada, 1961-62)

, 1963

openalex   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

Maintaining competence in radiation protection research: a position statement by the MELODI scientific advisory committee. [PDF]

Radiat Environ Biophys
Amundson SA, Belli M, Blettner M, Borgmann K, Forssell-Aronsson E, Harms-Ringdahl M, Jeggo PA, Niwa O, O'Neill P.   +8 more
europepmc   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

A reflection on paradigmatic tensions within the FDA advisory committee for MDMA-assisted therapy. [PDF]

J Psychopharmacol
Roseman L.
europepmc   +1 more source

The role of an ethics advisory committee in data science research in sub-Saharan Africa. [PDF]

S Afr J Sci, 2023
Kling S, Singh S, Burgess TL, Nair G.
europepmc   +1 more source

Report of the Joint Meeting of the Papers and Publications Advisory Committee and the Board of Editors [PDF]

, 1975
Thomas E. King
openalex   +1 more source

A “Mesoporous Oxygen Chamber” Scaffold with Antibacterial and Early Immunomodulatory Effect for Promoting Bone Regeneration

Advanced Science, EarlyView.
In this study, an oxygen‐loaded and antimicrobial peptide (AP)‐functionalized scaffold (MBGAPO) is synthesized. With mesoporous structure of MBG applied as an “oxygen storage,” and AP‐provided antibacterial ability against E.coli and MRSA. MBGAPO exhibited osteogenic and multiplex‐immunomodulatory effects.
You Fu, Dan Lin, Zhicen Lu, Jian Wang, Jing Zhao, Zhiyuan Zhang, Bing Fang, Xiao Yang   +7 more
wiley   +1 more source