Results 61 to 70 of about 1,082,218 (306)

South Lancashire Fisheries Advisory Committee 14th January, 1976. [PDF]

open access: yes, 1976
This is the report from the South Lancashire Fisheries Advisory Committee meeting, which was held on the 14th January 1976. The report contains information on land drainage representation on local committees, fisheries activities report, pollution on ...

core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Paediatric Association of Nigeria (PAN) recommended routine immunization schedule for Nigerian children Paediatric Association of Nigeria (PAN) recommended routine immunization schedule for Nigerian children

open access: yesNigerian Journal of Paediatrics
Vaccine preventable dis- eases are a major contributor to child morbidity and mortality espe- cially in the Sub-Saharan Africa and Nigeria in particular. It ac- counts for 17% of global total under -five mortality per year and 22% of child
PAN Advisory Committee on Immunisation
doaj  

Support for the 3rd Annual Exeter River Alewife Festival [PDF]

open access: yes, 2003
With support from the NH Estuaries Project (NHEP), the Exeter River Local Advisory Committee (ERLAC) held the 3rd Annual Exeter River Alewife Festival on May 31, 2003 in downtown Exeter.
Exeter River Local Advisory Committee
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Expanding (or Just Fixing) the Residual Exception to the Hearsay Rule [PDF]

open access: yes, 2017
The Judicial Conference Advisory Committee on Evidence Rules (“the Committee”) has been considering whether to amend Federal Rule of Evidence 807 (known as the residual exception to the hearsay rule) to improve the way the Rule functions—and also to ...
Capra, Daniel J.
core   +1 more source

The Advisory Committee on Immunization Practices’ Interim Recommendations for Additional Primary and Booster Doses of COVID-19 Vaccines — United States, 2021 [PDF]

open access: diamond, 2021
Sarah Mbaeyi   +21 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

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