Results 161 to 170 of about 53,784 (238)

From Ambition to Action: Barriers and Enablers for the Inclusion of Indigenous Peoples and Local Communities in the Kunming–Montreal Biodiversity Framework and the Role of Non‐State Bridge Organizations

Advanced Science, EarlyView.
Graphical abstract illustrating the transition from global biodiversity ambition to on‐the‐ground implementation of the Kunming–Montreal Global Biodiversity Framework after COP16, highlighting the roles of governments, non‐state actors, scientific knowledge systems, and resource mobilization in achieving transformative biodiversity outcomes.
Susan Enechojo Ogbe, Jinfeng Zhou, Linda Wong, Jiachen Gao   +3 more
wiley   +1 more source

Reply: Including Vonoprazan With PPIs Challenges the Drug-Interaction Hypothesis. [PDF]

JACC Asia
Nishikura T, Yamamoto K, Watanabe H, Morimoto T, Kimura T.   +4 more
europepmc   +1 more source

PHAC to publicly disclose conflicts of interest of external advisors serving on advisory committees. [PDF]

CMAJ, 2011
Collier R.
europepmc   +1 more source

Metal (n+1)p‐nd Orbital Hybridization and Excited‐State Metal–Ligand π‐Interactions Enable d10 Carbene‐Metal‐Amide TADF OLEDs with High Efficiency and Long Operational Lifetime

Advanced Science, EarlyView.
We elucidate the key roles of metal p‐d orbital hybridization, excited‐state metal–ligand π‐interactions, and structural rotation in TADF of d10 CMA complexes. Introducing electron‐withdrawing or π‐extended ligand substituents weakens excited‐state metal‐ligand π‐interactions and improves kTADF, but may compromise emitter stability in device operation.
Shuo Xu, Rui Tang, Qingyun Wan, Gang Cheng, Jun Yang, Chi‐Ming Che   +5 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Increased duration of time without transfusion reliance with imetelstat vs placebo in the phase 3 IMerge trial. [PDF]

Blood Neoplasia
Sekeres MA, Santini V, Zeidan AM, Platzbecker U, Komrokji RS, Díez-Campelo M, Fenaux P, Savona MR, Madanat YF, Valcárcel D, Regnault A, Mazerolle F, Sun L, Wan Y, Berry T, Feller F, Navada S, Oliva EN.   +17 more
europepmc   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Performance of Local Large Language Models for Adjudicating Heart Failure Hospitalizations. [PDF]

Circulation
Aggarwal R, Oseran AS, Manrai AK, Marinacci LX, Bhatt DL, Yeh RW, Ho JE, Rodman A, Wadhera RK.   +8 more
europepmc   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS. [PDF]

Blood Cancer J
Komrokji RS, Santini V, Zeidan AM, Sekeres MA, Fenaux P, Raza A, Mittelman M, Thépot S, Buckstein R, Germing U, Madanat YF, Díez-Campelo M, Valcárcel D, Jonášová A, Dougherty S, Shah S, Xia Q, Sun L, Navada S, Feller F, Savona MR, Platzbecker U.   +21 more
europepmc   +1 more source