Results 131 to 137 of about 547 (137)

Development of Cyclic Peptide‐Based Radiotracers for uPAR

ChemMedChem
The urokinase plasminogen activator (uPA) system has garnered attention as a promising biomarker, with the uPA receptor (uPAR) playing a central role in system regulation and demonstrating strong associations with tumorigenicity, invasion, and metastasis.
Xingkai Wang, Xu Zhang, Siqi Zhang, Lulu Zhang, Jieting Shen, Yingzi Zhang, Hailong Zhang, Ming-Rong Zhang, Rui Wang, Kuan Hu   +9 more
semanticscholar   +1 more source

Construction of Urokinase Type Plasminogen Activator Receptor (uPAR)-Targeted Heterostructures for Efficient Photothermal-Chemotherapy against Cervical Cancer to Achieve Simultaneous Anticancer and Antiangiogenesis.

ACS Applied Materials and Interfaces, 2019
Rational design and construction of theranostic nanomedicines based on clinical characteristics of cervical cancer is an important strategy to achieve precise cancer therapy. Herein, we fabricate a cervical cancer-targeting gold nanorod-mesoporous silica
Xiaoli Hu, Chetry Mandika, Lizhen He, Yuanyuan You, Yanzhou Chang, Jing Wang, Tianfeng Chen, Xueqiong Zhu   +7 more
semanticscholar   +1 more source

Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging

Protein Science
The urokinase‐type plasminogen activator receptor (uPAR) is currently gaining momentum as a promising molecular target for treatment of various solid cancers.
R. F. Anane, A. Kumari, Hari Venugopal, Sylvain Trépout, J. Whisstock, Lars H Engelholm, Ruby H P Law, M. Ploug   +7 more
semanticscholar   +1 more source

OS05.9.A TUMOR DELINEATION IN MENINGIOMA WITH FG001, A NOVEL UPAR-TARGETING FLUORESCENT AGENT FOR OPTIMIZING SURGERY

Neuro-Oncology
The principle of using a fluorescent agent for optimizing glioma surgery is well known. In surgery for meningioma this is less investigated. While FG001 (ICG-glu-glu-AE105), a uPAR-targeting peptide ligand, has proved high efficacy as a fluorescent
J. Skjoeth-Rasmussen, A. Azam, L. Lehmann, C. Larsen, A. Forsse, C. Sølling, M. Kryspin-Sørensen, K. Straede, B. Winther Kristensen, D. Scheie, A. Kjaer   +10 more
semanticscholar   +1 more source

Positron emission computed tomography targeting urokinase plasminogen activator receptor (uPAR) in cancer: a systematic review

Expert Review of Anticancer Therapy
Introduction To provide an overview of the available literature data on clinical applications of positron emission tomography (PET) targeting the urokinase-type plasminogen activator receptor in oncology.
Riccardo Camedda, V. Frantellizzi, Roberta Danieli, G. De Vincentis, Luca Filippi   +4 more
semanticscholar   +1 more source

Synthesis of 99Tcm-HYNIC-AE105 and its application for imaging urokinase plasminogen activator receptors in human pancreatic cancer xenografts by gamma imaging

, 2013
Fangfang Sun, Hongbo Feng, Chun Yang, Xin Zhang, Xiaoyan Gong, Guangyuan Wang, Di Li   +6 more
semanticscholar   +1 more source

Optimizing uPAR-targeting radiopeptides for improved tissue distribution: progress towards radionuclide therapy.

European Journal of Nuclear Medicine and Molecular Imaging
Christian Vaccarin, Darja Beyer, Jerome V Schmid, Bastian Klein, Jathursa Jegathasan, Shreshtha Behera, Xavier Deupi, R. Schibli, Cristina Müller   +8 more
semanticscholar   +1 more source