Results 71 to 80 of about 143,324 (245)

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Development of a confinable gene drive system in the human disease vector Aedes aegypti

bioRxiv, 2019
Aedes aegypti, the principal mosquito vector for many arboviruses that causes yellow fever, dengue, Zika, and chikungunya, increasingly infects millions of people every year. With an escalating burden of infections and the relative failure of traditional
Ming Li, Ting Yang, Nikolay P. Kandul, Michelle Bui, Stephanie Gamez, Robyn R. Raban, Jared B. Bennett, H. Sánchez C., G. Lanzaro, Hanno Schmidt, Yoosook Lee, John M. Marshall, O. Akbari   +12 more
semanticscholar   +1 more source

Powerful yet challenging: mechanistic niche models for predicting invasive species potential distribution under climate change

Ecography, EarlyView.
Risk assessments of invasive species present one of the most challenging applications of species distribution models (SDMs) due to the fundamental issues of distributional disequilibrium, niche changes, and truncation. Invasive species often occupy only a fraction of their potential environmental and geographic ranges, as their spatiotemporal dynamics ...
Erola Fenollosa, Sean E. H. Pang, Natalie J. Briscoe, Antoine Guisan, Roberto Salguero-Gómez   +4 more
wiley   +1 more source

Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population

Scientific Reports, 2019
In an attempt to control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing a dominant lethal gene has been developed by a commercial company, Oxitec Ltd.
Benjamin R. Evans, Panayiota Kotsakiozi, A. L. Costa-da-Silva, R. S. Ioshino, L. Garziera, Michele C. Pedrosa, A. Malavasi, J. F. Virgínio, M. Capurro, J. Powell   +9 more
semanticscholar   +1 more source

Influence of blood meal on the responsiveness of olfactory receptor neurons in antennal sensilla trichodea of the yellow fever mosquito, Aedes aegypti [PDF]

, 2010
In female Aedes aegypti L. mosquitoes, a blood meal induces physiological and behavioral changes. Previous studies have shown that olfactory receptor neurons (ORNs) housed in grooved peg sensilla on the antennae of Ae.
Hansson, Bill, Hill, Sharon, Ignell, Rickard, Siju, K.P.   +3 more
core   +1 more source

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage‐Dependent Calcium Channels and Protein Kinase C

Journal of Applied Toxicology, EarlyView.
ABSTRACT Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to ...
Bruna Antunes Zaniboni, Vanessa Staldoni de Oliveira, Gabriel Adan Araujo Leite, Valdelúcia Maria Alves de Souza Grinevicius, Rozangela Curi Pedrosa, Fátima Regina Mena Barreto Silva   +5 more
wiley   +1 more source

EFFECTIVENESS TEST OF OIL PALM LEAF EXTRACT (Elaeis guineensis Jacq.) AS A MOSQUITO BIOLARVACIDE Aedes aegypti

Jurnal Farmasi Sains dan Praktis
Dengue Hemorrhagic Fever (DHF) is a disease that is transmitted by female mosquito species Aedes aegypti which has spread all over the world. Efforts to control the Aedes aegypti mosquito vector by using natural biolarvicides using oil palm leaf extract.
Deni Setiawan, Samsul Hadi, Muhammad Riki Shindi, Nur Mahdi, Ririn Purnama Rinda   +4 more
doaj   +1 more source

Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions

PLoS Neglected Tropical Diseases, 2019
Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections are at a high frequency, they influence the local transmission of dengue by direct virus blocking as well as deleterious ...
Perran A. Ross, S. Ritchie, Jason K. Axford, A. Hoffmann   +3 more
semanticscholar   +1 more source

Dispersal of _Aedes aegypti_: field study in temperate areas and statistical approach [PDF]

, 2012
We studied the dispersion of _Aedes aegypti_ during egg laying in natural conditions. Two independent experiments involving mosquitoes dispersing from urbanization towards adjacent un-urbanized areas were carried out and analyzed in statistical terms. We
Carlos A. Ruggerio, Herná, Nicolá, Paula Bergero, Rubé   +4 more
core   +1 more source

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna, Liu, Jisheng, Smagghe, Guy, Swevers, Luc   +3 more
core   +1 more source