Results 61 to 70 of about 288,912 (350)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Abundance of harbor porpoise (Phocoena phocoena) in three Alaskan regions, corrected for observer errors due to perception bias and species misidentification, and corrected for animals submerged from view [PDF]

, 2010
Estimating the abundance of cetaceans from aerial survey data requires careful attention to survey design and analysis. Once an aerial observer perceives a marine mammal or group of marine mammals, he or she has only a few seconds to identify and ...
Hobbs, Roderick C., Waite, Janice M.
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Protected species aerial survey data collection and analysis in waters underlying the R-5306A airspace: final report submitted to US Marine Corps, MCAS Cherry Point [PDF]

, 2007
To be in compliance with the Endangered Species Act and the Marine Mammal Protection Act, the United States Department of the Navy is required to assess the potential environmental impacts of conducting at-sea training operations on sea turtles and ...
Braun-McNeill, Joanne, Davenport, Erik, Goodman, M. April, Hohn, Aleta A.   +3 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A review of climatic and vegetation surveys in urban environment with laser scanning: A literature-based analysis [PDF]

Geographica Pannonica, 2019
Laser scanning is a promising relatively new technology of land surveying and has different contributions to research areas and practical applications. We performed a review based on query terms in the Scopus database.
Szabó Zsuzsanna, Schlosser Aletta, Túri Zoltán, Szabó Szilárd   +3 more
doaj  

Unmanned Aircraft Systems in Remote Sensing and Scientific Research: Classification and Considerations of Use

Remote Sensing, 2012
Unmanned Aircraft Systems (UAS) have evolved rapidly over the past decade driven primarily by military uses, and have begun finding application among civilian users for earth sensing reconnaissance and scientific data collection purposes.
Adam C. Watts, Everett A. Hinkley, Vincent G. Ambrosia   +2 more
doaj   +1 more source

A Survey of Air-to-Ground Propagation Channel Modeling for Unmanned Aerial Vehicles

, 2018
In recent years, there has been a dramatic increase in the use of unmanned aerial vehicles (UAVs), particularly for small UAVs, due to their affordable prices, ease of availability, and ease of operability.
Aboudebra A., Ahmed N., Alzenad Mohamed, Alzenad Mohamed, Al‐Hourani A., Amorim R., Amorim R., Asadpour M., Athukoralage Dasun, Azari M. M., Bandoim Lana, Blandino Steve, Bluemm Christian, Bohagen Frode, Bor‐Yaliniz R Irem, Cai X., Chandhar P., Chen J., Chen J., Cheng Chen‐Mou, Cheng Xiang, Child JR, Daniel Kai, David Blom John, Desjardins Jeff, Essaadali R., Feng Qixing, Gao Xijun, Gates B. G., George Pierce Jones IV, Goddemeier N., Goddemeier Niklas, Gulfam S. M., Gulfam S. M., Hemanth Kumar Zhiqiang Wu, Ibrahim M., Jackson B. R. P., Jamal Hosseinali, Jiang F., Johnsson J., Joo Park Pyung, Kalantari E., Kaul S., Kawamata F., Kerczewski Bob, Khawaja W., Khawaja Wahab, Khawaja Wahab, Khawaja Wahab, Kovacs I., Ksendzov Alexander, Kung H. T., Kunisch J., Kvicera Milan, Lamiano D. F., Lemos Cid E., Levis Curt, Lin X., Lyu J., Malik W. Q., Matolak D. W., Matolak D. W., Matolak D. W., Matolak D. W., Matolak D. W., Matolak D. W., Matolak D. W., Matolak David W, Matolak David W., Matolak David W., Matolak David W., Newhall W. G., Ono F., Paier A., Pavel Pechac Michal Simunek, Rappaport T. S., Ravi V. V. C., Rieth D., Romeu J., Ruddle A. R., Schneckenburger N., Sharp C. S., Shim D. H., Song Meng Yu, Sun R., Sun Ruoyu, Sun Ruoyu, Takizawa K., Tavares T., Teng E., Tu H. D., Vahidi Vahid, Walter Michael, Wentz Michael, White F., Wu Y., Yang J., Yanmaz Evşen, Yanmaz Evşen, Zelenỳ Jan, Zhang Chao, Zheng Yi   +101 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Comparison of Sampling Strategies to Estimate Abundance of Double-Crested Cormorants in Western Mississippi

Human-Wildlife Interactions, 2017
We compared 2 sampling strategies designed to estimate abundance of double-crested cormorants (Phalacrocorax auritus, hereafter cormorants) on aquaculture ponds in western Mississippi.
Aaron T. Pearse , Brian S. Dorr, Stephen J. Dinsmore, Richard M. Kaminski   +3 more
doaj   +1 more source