Results 161 to 170 of about 1,321,737 (343)

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Aerobic Fitness, Acute Exercise and Sleep in Older Men

, 1993
Jack D. Edinger, Miriam C. Morey, Robert J. Sullivan, Michael B. Higginbotham, Gail R. Marsh, Dorothy S. Dailey, W. Vaughn McCall   +6 more
openalex   +1 more source

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine

Advanced Science, EarlyView.
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li, Yuanyi Zhang, Chenchen Li, Guoping Chen, Pir Muhammad, Yonghong Yao, Lifang Gao, Zhigang Liu, Yanli Wang   +8 more
wiley   +1 more source

INFLUENCE OF AEROBIC EXERCISE TRAINING ON THE RELATIONSHIP BETWEEN OXYGEN UPTAKE AND HEART RATE RESERVE IN THE ELDERLY

, 1992
J. E. Graves, L. B. Panton, M. L. Pollock, L. Garzarella, Joan F. Carroll, G. Guillen, David Löwenthal   +6 more
openalex   +1 more source

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

Advanced Science, EarlyView.
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu, Jie Zhang, Hengxing Chen, Haobin Hou, Huanjie Chen, Rongman Xie, Yanlei Chen, Jian Zhang, Dehua Liu, Leping Yan, Rui L. Reis, Joaquim M. Oliveira, Yulong He, Li Zhong, Qinbo Cai, Dongjie Yang   +15 more
wiley   +1 more source

Effect of a six-month aerobic exercise training program on cardiovascular responsivity in healthy middle-aged adults

, 1992
Cheryl L. Albright, ­Abby C. King, C. Barr Taylor, William L. Haskell   +3 more
openalex   +1 more source

Randomized trial of the short-term effects of dieting compared with dieting plus aerobic exercise on lactation performance [PDF]

, 1999
Megan A. McCrory, Laurie Nommsen‐Rivers, P. A. Molé, Bo Lönnerdal, Kathryn G. Dewey   +4 more
openalex   +1 more source

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2016
D. Kitzman, P. Brubaker, T. Morgan, M. Haykowsky, Gregory W. Hundley, W. Kraus, Joel D. Eggebeen, B. Nicklas   +7 more
semanticscholar   +1 more source

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Advanced Science, EarlyView.
ASP aggravates TEC injury and phenotypic transformation via mitochondrial dynamics disorder mediated by excessive Drp1 SUMOylation in DKD mice. However, either ASP deficiency or AASP effectively alleviates the kidney injury and mitochondrial dynamics disorder induced by STZ/HFD, highlighting that ASP could be an early diagnostic marker and potential ...
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang   +8 more
wiley   +1 more source

Improvement in Iron Deficiency Anemia through Therapy with Ferric Ammonium Citrate and Vitamin C and the Effects of Aerobic Exercise.

, 1991
Misako Taniguchi, Hideo Imamura, Tomoko Shirota, Hiroshi OKAMATSU, Yasuhiro Fujii, Masamichi Toba, Fumio Hashimoto   +6 more
openalex   +2 more sources