Results 181 to 190 of about 115,025 (337)

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

open access: yesAdvanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua   +19 more
wiley   +1 more source

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

open access: yesAdvanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling   +12 more
wiley   +1 more source

Ru complexes containing N‐methyl‐1,3,5‐triaza‐7‐phosphaadamantane (mPTA) as catalysts for the isomerization of 2‐cyclohexen‐1‐ol

open access: yesApplied Organometallic Chemistry, Volume 37, Issue 2, February 2023., 2023
The paper discusses the catalytic activity of [RuCp(H2O‐κO)(mPTA)2](CF3SO3)3 for the isomerization of the cyclic allylic alcohol 2‐cyclohexen‐1‐ol with good conversion and negligible metal losses. The complex [RuCp(H2O‐κO)(mPTA)2](CF3SO3)3·MeOH (4·MeOH) was synthesized and characterized by spectroscopic techniques and its crystal structure determined ...
Belén López‐Sánchez   +3 more
wiley   +1 more source

The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding. [PDF]

open access: yesSci Rep
Silva DGM   +9 more
europepmc   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu   +13 more
wiley   +1 more source

Electronic CPA‐Laser Having Enhanced Sensitivity and Tunability

open access: yesAdvanced Electronic Materials, EarlyView.
Coherent perfect absorber (CPA) laser points are peculiar singularities possessed by parity−time symmetric systems. They have demonstrated great potential for sensing applications, albeit hindered by the non‐tunability and structural limitations. This work introduces a tunable CPA laser system in a reader‐sensor scheme, whose sensitivity can be further
Minye Yang   +7 more
wiley   +1 more source

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