Results 51 to 60 of about 115,025 (337)

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Effects of circuit exercise training on vascular health and blood pressure

Preventive Medicine Reports, 2018
As the global burden of cardiovascular disease (CVD) rises, public health-related interventions aimed at prevention of heart disease have gained medical attention.
Allyson K. Getty, Tia R. Wisdo, Lauren N. Chavis, Cassandra C. Derella, Kelly C. McLaughlin, Avery N. Perez, William T. DiCiurcio, III, Meaghan Corbin, Deborah L. Feairheller   +8 more
doaj  

Oxygen consumption during concurrent training: influence of intra-session exercise sequence and aerobic exercise modality

Biology of Sport, 2018
To compare the acute effects of different intra-session exercise sequences and aerobic exercise modalities during concurrent training sessions on oxygen consumption (VO 2 ) and energy expenditure (EE) in young women.
Rodrigo Ferrari, Cristine Alberton, Stephanie Pinto, Eduardo Cadore, Ronei Pinto, Luiz Fernando Kruel   +5 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Finding Similar Exercises in Retrieval Manner [PDF]

37th Conference on AAAI 2023 Artificial Intelligence for Education(AI4Edu), 2023
When students make a mistake in an exercise, they can consolidate it by ``similar exercises'' which have the same concepts, purposes and methods. Commonly, for a certain subject and study stage, the size of the exercise bank is in the range of millions to even tens of millions, how to find similar exercises for a given exercise becomes a crucial ...
arxiv  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

The effect of eight weeks of interval aerobic training with the consumption of crocetin extract on some indices of angiogenesis of the heart tissue of prediabetic and diabetic aged rats [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background and aims: Diabetes is associated with cardiovascular and metabolic disorders. Although the favorable role of physical activity and antioxidants in people's health has been reported, the simultaneous effect of HIIT and crocetin on angiogenesis ...
Shahram Pouya, khosro jalali dehkordi, Farzaneh Taghian, Mehdi Kargarfard, seyed Ali Hoseini   +4 more
doaj  

Effects of aerobic exercise on anxiety sensitivity [PDF]

Behaviour Research and Therapy, 2004
Anxiety sensitivity is a known precursor to panic attacks and panic disorder, and involves the misinterpretation of anxiety-related sensations. Aerobic exercise has been shown to reduce generalized anxiety, and may also reduce anxiety sensitivity through exposure to feared physiological sensations.
Broman-Fulks, Joshua J., Berman, Mitchell E., Rabian, Brian A., Webster, Michael J.   +3 more
openaire   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source