Results 101 to 110 of about 163,328 (242)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Innovative concepts for aerodynamic control of wind turbine rotors [PDF]
, 1992 New systems for the aerodynamic control of wind turbine rotors are being studied in various projects funded by the UK Department of Energy. Results from a current project, ongoing at the National Wind Turbine Test Centre (NWTC) in Scotland are presented.
JAMIESON, P +4 more
core +1 more source
Experimental and Numerical Research on End-Wall Flow Mechanism of High-Loading Tandem Stators
Applied SciencesTandem blades have been recognized for their potential to enhance the loading capacity of compressors. However, tandem stators currently do not exhibit advantages due to insufficient understanding of the complex end-wall flow mechanisms. To address this,
Chuanhai Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
DG Methods for Aerodynamic Flows: Higher order, error estimation and adaptive mesh refinement [PDF]
, 2011 Discontinuous Galerkin (DG) methods allow higher-order flow solutions on unstructured or locally refined meshes by increasing the polynomial degree and using curved instead of straight-sided elements. Aerodynamic force coefficients like the drag, lift
Hartmann, Ralf
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Aerodynamic Decelerator Systems Center (archived) [PDF]
, 2001 The Aerodynamic Decelerator Systems Center (ADSC) was founded in 2001 and currently pursues the following objectives: Continue supporting the Affordable Guided Airdrop System precision airdrop capability; a circular-parachute guided cargo system; Support
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