Results 111 to 120 of about 9,635,660 (350)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Identification of Turbocharger Noise Sources Taking into Account Design Operating Conditions
MachinesThe paper describes in detail the creation of selected aerodynamic sound sources created by the centrifugal compressor of the turbocharger in operating modes.
Jozef Doman +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MATEC Web of Conferences, 2018 In this paper a computational methodology of aerodynamic interaction between propeller and wing is described. Presented work is focused on development of quick and accurate tool.
Pavel Hospodář +2 more
doaj +1 more source
Application of CFD techniques toward the validation of nonlinear aerodynamic models [PDF]
Applications of Computational fluid dynamics (CFD) methods to determine the regimes of applicability of nonlinear models describing the unsteady aerodynamic responses to aircraft flight motions are described.
Katz, J., Schiff, L. B.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Simulation of airflow pattern of two rotating cylinders
Қарағанды университетінің хабаршысы. Физика сериясы, 2016 The article discusses calculations of numerical simulation of airflow pattern of two rotating cylinders at low wind speed. The authors obtained universal dependences on aerodynamic characteristics of the incoming flow rate at a constant angular velocity.
K. Kussayinov +5 more
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Numerical Simulation on Non-Synchronous Aerodynamic Excitation of Axial Compressor Rotor Blades
气体物理In order to reveal the flow mechanism of non-synchronous aerodynamic excitation at rotor tip region of axial compressor, the unsteady flow field of a 1.5-stage compressor under near-stall conditions was simulated using the detached eddy simulation (DES ...
Songbai WANG +4 more
doaj +1 more source
Numerical study on aerodynamic effects in passive pitching dynamics of insect flapping wings
Nihon Kikai Gakkai ronbunshu, 2014 This study is concerned with aerodynamic effects in passive pitching dynamics of insect flapping wings, which would be based on the Fluid-Structure Interaction (FSI). Thus, we evaluated them using three-dimensional numerical analyses for the FSI based on
Daisuke ISHIHARA +2 more
doaj +1 more source