MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Multi-objective design optimization for high-lift aircraft configurations supported by surrogate modeling [PDF]
, 2013 Nowadays, the competition among airlines seriously depend upon the saving operating costs, with the premise that not to degrade its services quality.
Li, Daxin
core
, 2011 PhDThe study of rotor blade aerodynamic performances of wind tur- bine has been presented in this thesis. This study was focused on aero- dynamic effects changed by blade surface distribution as well as grid solution along the airfoil.
Emrah Kulunk, Horikiri, Kana
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Nonlinear Modeling Study of Aerodynamic Characteristics of an X38-like Vehicle at Strong Viscous Interaction Regions. [PDF]
Entropy (Basel), 2022 Jiang D, Wang P, Li J, Mao M.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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The Normative Study of Acoustic and Aerodynamic Characteristics of Voice among Healthy Adult Turkish Speaker Population. [PDF]
Biomed Res Int, 2021 Şen AZ, Toğram B.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Small Wind Turbine Starting Behaviour [PDF]
, 2012 Small wind turbines that operate in low-wind environments are prone to suffer performance degradation as they often fail to accelerate to a steady, power-producing condition. The behaviour during this process is called “starting behaviour” and it is the
WORASINCHAI, SUPAKIT
core
Aerodynamic Characteristics and Lateral Displacements of a Set of Two Buildings in a Linked Tall Building System. [PDF]
Sensors (Basel), 2021 Chen Z, Kim B, Lee DE.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source