Results 211 to 220 of about 15,596,670 (337)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Evaluation of HYFLEX aerodynamic characteristics

open access: yesEvaluation of HYFLEX aerodynamic characteristics
24-25 Jul. 1996 24-25 Jul. 1996 HYFLEX(極超音速飛行実験)機の飛行実験において取得された空力特性データと風洞試験およびCFD(数値流体力学)に基づく予測値を比較することにより、HYFLEXにおいて使用した空力特性予測手法の妥当性を評価する。本稿が対象とするのは、空力係数、縦トリム特性、エレボン・ヒンジモーメントと機体表面圧力分布である。飛行試験と予測値の比較の結果、HYFLEXの空力設計において適用した空力特性予測手法は、全般的に妥当なものであることが検証された。しかし、軸力係数、トリム舵角などについては、予測値と飛行結果の間に設計で考慮したUncertainty以上の差異が見られたため、その原因について考察した。 HYFLEX (Hypersonic ...
openaire   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Aerodynamic Characteristics of Simplified Waveriders

open access: yesAerodynamic Characteristics of Simplified Waveriders
資料番号 ...
openaire   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

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