Results 61 to 70 of about 20,749 (266)

The Aerodynamic Characteristics of Road Vehicles Overtaking on Bridge Deck under Crosswinds

Advances in Civil Engineering, 2020
The aerodynamic characteristics of road vehicles in windy environments are the prerequisites for the evaluation and prediction of the driving safety and stability.
Ning Chen, Hongxin Sun, Xiuyong Wang, Longwei Zhang   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Simulation and Analysis of Aerodynamic Characteristics during Parafoil Canopy Curving Process and Application by LBM

Aerospace
A parafoil is a crucial aerodynamic deceleration device used in the field of airdrop. The overall objective of this paper is to study the aerodynamic characteristics of the curving process of the canopy using the lattice Boltzmann method, to verify it ...
Yi Wang, Chunxin Yang
doaj   +1 more source

The influence of aerodynamic coefficients on the elements of classic projectile paths

Vojnotehnički Glasnik, 2011
The article deals with the results of the research on the influence of aerodynamic coefficient values on the trajectory elements and the stability parameters of classic axisymmetric projectiles.
Damir D. Jerković, Dušan B. Regodić
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dipole Approximation in the Calculation of the Perturbed Velocities

Transport and Telecommunication, 2014
In this article we consider one of the approaches aimed at reducing time of calculation of aerodynamic characteristics of the studied objects using discrete vortex method.
Solovyov Oleg, Yeryomenko Sergey, Kobrin Vitaliy, Vorobyov Yuriy   +3 more
doaj   +1 more source

Low Reynolds Number Propeller Slipstream Interference with Wing Aerodynamic Characteristics

Hangkong gongcheng jinzhan, 2018
Detailed research for wing aerodynamic characteristics of propeller slipstream at low Reynolds number could contribute the mechanism study of low speed near space flow, and provide reliable aerodynamic results.
Sun Kaijun, Bao Xiaoxiang, Fu Yiwei
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source