Results 91 to 100 of about 19,794 (265)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Aerodynamic Characteristics and Lateral Displacements of a Set of Two Buildings in a Linked Tall Building System. [PDF]

Sensors (Basel), 2021
Chen Z, Kim B, Lee DE.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparison of anatomic and aerodynamic characteristics of the upper airway among edentulous mild, moderate, and severe obstructive sleep apnea in older adults. [PDF]

J Clin Sleep Med, 2022
Chen H, Elham E, Li Y, Ge S, Schmittbuhl M, Lavigne G, van der Stelt PF, Huynh N.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

MULTI-OBJECTIVE OPTIMIZATION DESIGN OF MW WIND TURBINE AIRFOILS

Jixie qiangdu, 2020
With the development of wind power generation technology,the requirements for various performances of wind turbines are higher. Aerodynamic noise problem has become a key research direction of the wind power industry.
LI YingJue, WEI KeXiang, ZHOU Zhou
doaj  

Aerodynamic characteristics in upper airways among orthodontic patients and its association with adenoid nasopharyngeal ratios in lateral cephalograms. [PDF]

BMC Med Imaging, 2021
Feng X, Chen Y, Cai W, Lie SA, Hellén-Halme K, Shi XQ.   +5 more
europepmc   +1 more source

Aerodynamic Characteristics of HYFLEX.

Journal of the Japan Society for Aeronautical and Space Sciences, 1997
WATANABE, Shigeya, ISHIMOTO, Shinji, TAKAKI, Ryoji   +2 more
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The Refined Simulation Methods of Fluctuating Wind and Aerodynamic Forces Relative to Moving Trains

Applied Sciences
This study proposes a framework to accurately simulate the fluctuating wind and aerodynamic forces relative to moving trains. It provides a novel method for calculating the power spectra of the fluctuating wind relative to moving trains and the time ...
Naijie Yan, Ning Chen, Aiqiong Tang, Yonghua Su, Hui Guo, Qiqi Xiang   +5 more
doaj   +1 more source