Results 41 to 50 of about 38,138 (315)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Influence of permeability characteristics on the aerodynamic characteristics of airfoils

Hangkong gongcheng jinzhan
Feathers play an important role in bird flight activities, and porous media materials may be used to simulate the air permeability of bird feathers.
LI Fukun, HAO Lishu, BAO Haiwei, GAO Yongwei   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transonic aerodynamic loads modeling of X-31 aircraft pitching motions

, 2013
The generation of reduced-order models for computing the unsteady and nonlinear aerodynamic loads on an aircraft from pitching motions in the transonic speed range is described.
Cummings, R.M., Da Ronch, A., Badcock, K.J., Ghoreyshi, M.   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An investigation into the mechanical damping characteristics of catenary contact wires and their effect on aerodynamic galloping instability

, 2003
Measurement of the damped oscillation of a section of the UK East Coast Main Line (ECML) catenary/contact wire system was undertaken, and the natural frequency and mechanical damping were found to be 1.4Hz and 0.05 respectively. This information was used
Craighead, I.A., Scanlon, T.J., Stickland, M.T., Fernandez, J.   +3 more
core   +1 more source

Identification and Modeling Method of Longitudinal Stall Aerodynamic Parameters of Civil Aircraft Based on Improved Kirchhoff Stall Aerodynamic Model

Aerospace, 2023
The stall aerodynamic model based on Kirchhoff’s theory of flow separation is widely used in the identification and modeling of stall aerodynamic parameters. However, it has two defects.
Lixin Wang, Rong Zhao, Ke Xu, Yi Zhang, Ting Yue   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Transonic aerodynamic loads modeling of X-31 aircraft

, 2012
The generation of reduced order models for computing the unsteady and nonlinear aerodynamic loads on the X-31 aircraft from pitching motions in the transonic speed range is described.
Cummings, R. M., Post, M. L., Da Ronch, A., Badcock, K. J., Ghoreyshi, M.   +4 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source