Results 71 to 80 of about 38,138 (315)

The Aerodynamic Characteristics of Road Vehicles Overtaking on Bridge Deck under Crosswinds

open access: yesAdvances in Civil Engineering, 2020
The aerodynamic characteristics of road vehicles in windy environments are the prerequisites for the evaluation and prediction of the driving safety and stability.
Ning Chen   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Effect of cross wind on aerodynamic coefficients of ground vehicles.

open access: yes, 2009
The present work investigates the variation of aerodynamic coefficients with the change in the angle of flow. A mathematical equation has been developed for predicting the aerodynamic coefficients, when a vehicle is subjected to crosswind.
Malviya, Vihar   +2 more
core  

A new method for predicting the vortex induced aerodynamic characteristics of a body of revolution [PDF]

open access: yes, 1995
The problem of mathematically modelling the symmetric vortex pair formed on the lee side of a body of revolution at moderate incidence to the freestream direction is addressed with a view to predicting its aerodynamic characteristics.
Smith, Howard
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

PrandtlPlane High–Lift System Preliminary Aerodynamic Design

open access: yes, 2006
An analysis of low-speed aerodynamics for an unconventional aircraft configuration has been carried out. This configuration, named Prandtlplane, implements Prandtl's Best Wing System for low induced drag.
Iezzi, Giuseppe
core  

Some experimental and theoretical studies in aircraft stability at high angles of attack [PDF]

open access: yes, 1983
A review of techniques for stability and response investigations is presented and the averaging technique of Beecham- Titchener-Simpson is applied to the lateral equations of. motion for two combat aircraft.
Thorne, R.
core  

Towards computational flight dynamics of a passenger jet aircraft

open access: yes, 2014
This paper investigates the efficient generation of an aerodynamic database for flight simulation of a regional jet aircraft. A hierarchy of aerodynamic models is used, from semi–empirical approaches up to computational fluid dynamics analyses.
Wang, Yongzhi   +2 more
core   +1 more source

Simulation and Analysis of Aerodynamic Characteristics during Parafoil Canopy Curving Process and Application by LBM

open access: yesAerospace
A parafoil is a crucial aerodynamic deceleration device used in the field of airdrop. The overall objective of this paper is to study the aerodynamic characteristics of the curving process of the canopy using the lattice Boltzmann method, to verify it ...
Yi Wang, Chunxin Yang
doaj   +1 more source

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