Results 41 to 50 of about 147,888 (314)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Identification and Modeling Method of Longitudinal Stall Aerodynamic Parameters of Civil Aircraft Based on Improved Kirchhoff Stall Aerodynamic Model

Aerospace, 2023
The stall aerodynamic model based on Kirchhoff’s theory of flow separation is widely used in the identification and modeling of stall aerodynamic parameters. However, it has two defects.
Lixin Wang, Rong Zhao, Ke Xu, Yi Zhang, Ting Yue   +4 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Aerodynamics of Bluff Bodies and the Possibility of its Application in the Design of Trucks. Analytical Review

Механика машин, механизмов и материалов, 2011
The paper presents an overview of research in the field of aerodynamics of bluff bodies and some useful flows which are used in theoretical studies on the aerodynamics of aircraft.
V.S. Karabtsev , D.H. Valeev
doaj  

Effect of aerodynamic braking plates installed in Inter-car gap on aerodynamic characteristics of high-speed train

Alexandria Engineering Journal, 2023
With the continuous increase of train speeds, the aerodynamic drag force provided by aerodynamic braking plates can effectively solve problems of insufficient emergency braking force.
Yifan Li, Tian Li, Jiye Zhang
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Novel Aerodynamic Modeling Method Based on Data for Tiltrotor evtol

Applied Sciences
A data-driven aerodynamic modeling method is proposed to address the problem that traditional modeling methods based on physical mechanisms cannot fully represent the special aerodynamic characteristics of tiltrotor evtol aircraft.
Haiyang Wang, Peng Li, Dongsu Wu
doaj   +1 more source

Some solvable non-linear equations related to aerodynamic instability phenomena

Vietnam Journal of Mechanics, 1994
This article proposes some forms of aerodynamic forces, looks for accurate solutions of core - pendent non-linear differential equations and analyses the characteristics of aerodynamic forces and of equation's solution.
Nguyen Dang Bich, Nguyen Vo Thong
doaj   +1 more source