Results 91 to 100 of about 914,181 (280)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Active Flow Separation Control on a High-Lift Wing-Body Configuration. Part 2: The Pulsed Blowing Application. [PDF]

, 2011
This contribution discusses the implementation of active flow separation control for a 3D high-lift wing-body configuration under atmospheric low-speed wind tunnel conditions.
Rudnik, Ralf, Bauer, Matthias, Kühn, Timo, Ciobaca, vlad, Gölling, Burkhard   +4 more
core  

Analysis of Structural Characteristics of the HALE Joined-Wing Configuration UAV

International Journal of Aerospace Engineering
This study focuses on a high-altitude long-endurance (HALE) joined-wing configuration UAV and completes a preliminary structural design based on aircraft design indices and the fundamental principles of aircraft structure design. Based on the preliminary
Junlei Sun, Ye Zhou, Zhou Zhou, Zhengping Wang   +3 more
doaj   +1 more source

Automotive aerodynamic reduced-order prediction based on physics-guided block design neural network

Results in Engineering
To address the high computational cost of CFD simulations, the increased sample requirements caused by high-dimensional design variables, and the limited generalization capability of traditional surrogate models in automotive aerodynamic optimization ...
Xiaowen Zang, Yingchao Zhang, Ruizhuo Zhou, Jinji Li, Zhe Zhang   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Aerodynamic interactions analysis of propeller configurations and spatial parameters on a twin-boom unmanned aerial vehicle

Engineering Applications of Computational Fluid Mechanics
To overcome the technical bottleneck in aircraft design where aerodynamic and propulsion systems are treated separately, an integrated actuator disk model (ADM) simulation platform based on blade element momentum theory (BEMT) was developed, enabling ...
Xiaolu Wang, Changning Chen, Yingyu Liu, Daijun Liu, Mingqiang Luo   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Numerical Investigation of Aerodynamic Interactions in a Twin-Propeller Compound Helicopter

Aerospace
High-speed compound helicopters surpass the forward-speed limits of conventional helicopters and expand the flight envelope, yet close multi-component integration induces complex aerodynamic interference, whose underlying mechanisms and evolution with ...
Yutong Wang, Jiahao Song, Haomiao Xia, Qinchuan Hou   +3 more
doaj   +1 more source