Results 41 to 50 of about 914,181 (280)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Transonic aerodynamic loads modeling of X-31 aircraft pitching motions
, 2013 The generation of reduced-order models for computing the unsteady and nonlinear aerodynamic loads on an aircraft from pitching motions in the transonic speed range is described.
Cummings, R.M. +3 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Effects of turbulence modelling on the analysis and optimisation of high-lift configurations [PDF]
, 2011 Due to the significant effects on the performance and competitiveness of aircraft, high lift devices are of extreme importance in aircraft design. The flow physics of high lift devices is so complex, that traditional one pass and multi-pass design ...
Guo, Chuanliang.
core +5 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Applied Sciences, 2019 The high-speed-train pantograph is a complex structure that consists of different rod-shaped and rectangular surfaces. Flow phenomena around the pantograph are complicated and can cause a large proportion of aerodynamic noise, which is one of the main ...
Yongfang Yao +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Aerodynamic Concept of the UAV in the Gyrodyne Configuration [PDF]
Transactions on Aerospace Research, 2018 Abstract The article presents an aerodynamic concept of UAV in the gyrodyne configuration, as a more efficient one than the currently used UAV airframe configuration applied for monitoring tasks of power lines and railway infrastructure.
Jan Muchowski +2 more
openaire +1 more source