Results 131 to 140 of about 1,044,517 (354)
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
ComputationThis study presents a detailed computational investigation of unsteady laminar flow around two-dimensional square cylinders arranged in multiple configurations. Simulations were performed using ANSYS Fluent 2019 at Reynolds numbers ranging from 50 to 200,
Sunil Chamoli +9 more
doaj +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
MathematicsConsidering the influence of high-speed obstacle avoidance trajectory in the optimization design stage of intelligent bus aerodynamic shape. A collaborative optimization method aiming at aerodynamic structure and trajectory control system for intelligent
Tingting Wang +5 more
doaj +1 more source
External store effects on the stability of fighter and interceptor airplanes [PDF]
Some criteria for external carriage of missiles for fighter aircraft intended for aerial combat missions and for fighter-interceptor missions are considered.
Sawyer, W. C., Spearman, M. L.
core +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
A computer program to generate equations of motion matrices, L217 (EOM). Volume 1: Engineering and usage [PDF]
The equations of motion program L217 formulates the matrix coefficients for a set of second order linear differential equations that describe the motion of an airplane relative to its level equilibrium flight condition.
Clemmons, R. E., Kroll, R. I.
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Cruise aerodynamics of USB nacelle/wing geometric variations [PDF]
Experimental results are presented on aerodynamic effects of geometric variations in upper surface blown nacelle configurations at high speed cruise conditions.
Braden, J. A. +2 more
core +1 more source