Results 121 to 130 of about 131,365 (295)
Simulation on Buffet Response and Mitigation of Variant-Tailed Aircraft in Maneuver State
VibrationThis study proposes a computational fluid dynamics and computational structure dynamics (CFD/CSD) coupled method for calculating the buffet response of a variant tail wing.
Dawei Liu +6 more
doaj +1 more source
Sinusoidal-gust generation with a pitching and plunging airfoil
, 2019 The generation of uniform, periodic gust disturbances in an experimental context is demonstrated using a single oscillating airfoil. A pitching and heaving symmetric airfoil is suggested as a simpler alternative to existing gust-generation methods.
Kissing, Johannes +2 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
CHANCE: A FRENCH-GERMAN HELICOPTER CFD-PROJECT [PDF]
, 2006 The paper gives an overview of the CHANCE research project (partly supported by the French DPAC and DGA and the German BMWA) which was started in 1998 between the German and French Aerospace Research Centres DLR and ONERA, the University of Stuttgart and
Altmikus, Andree +4 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Application of multidisciplinary optimization methods to the design of a supersonic transport [PDF]
An optimization design method is discussed. This method is based on integrating existing disciplinary analysis and sensitivity analysis techniques by means of generalized sensitivity equations.
Barthelemy, J.-F. M. +5 more
core +1 more source
Determination of wind turbine far wake using actuator disk [PDF]
, 2014 The growth in size of wind turbines over the last years is significant. The rotor diameter becomes somehow comparable to atmospheric boundary layer at the land surface. In this case the assumption of uniform velocity of upcoming wind cannot be valid. The
AMER, Rodeyna +2 more
core +3 more sources
Shape Memory Alloys Applied to Automotive Adaptive Aerodynamics [PDF]
, 2023 Miriam Battaglia +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source