Results 51 to 60 of about 1,824,819 (310)

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Evaluation of Rare Hand Injection Injuries With Three Different Substances

Case Reports in Surgery
Injection injuries to the hand are rare and often underestimated in the initial evaluation due to minor external findings and mild symptoms. However, these injuries can lead to local and systemic complications with mechanical and toxic damage mechanisms.
Hasan Basri Çağlı, Salih Can Sezer, Abdurrahman Ercan Yurttaşer, Ahmet Özdemir, Tahir Babahan, Merve Özger, Mustafa Yılmaz   +6 more
doaj   +1 more source

Pregnancy and delivery after lower body contouring surgery is safe for the mother and child [PDF]

, 2021
Background: Obesity in fertile age women has increased worldwide leading to increased bariatric procedures. Lower body contouring surgery (LBCS) is one of the most commonly performed esthetic operations, mainly owing to massive weight loss.
Pajula, S, Jyranki, J, Koljonen, V, Kaijomaa, Marja, Jyränki, Janne, Tukiainen, Erkki, Tukiainen, E, Gissler, Mika, Koljonen, Virve, Gissler, M,, Kaijomaa, M, Pajula, Susanna   +11 more
core   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Surgical Correction of Tear Trough Deformity (TTD) with Orbicularis Retaining Ligament Release and Volume Augmentation for Periorbital Rejuvenation: Review of the Literature [PDF]

, 2023
Background: Tear trough deformity is a hallmark of periorbital aging. It is not, however, an exclusive feature of old age. While protruding orbital fat results in lower lid bags that are traditionally corrected by excision, correction of TTD can ...
Chahine, Fadl M., Atiyeh, Bishara Shafic, Hakim, Christopher Alain, Oneisi, Ahmad K., Ghieh, Fadi M.   +4 more
core   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Complications and Clinical Outcomes Following Modified Endoscopic Denker's With Pyriform Aperture Preservation: A Prospective Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The modified endoscopic Denker's (MED) approach provides access to all maxillary sinus (MS) walls for resection of various MS and retromaxillary pathologies, but the anteromedial maxilla has historically been resected. This study determined complication rates and outcomes following MED with pyriform aperture (PA) preservation ...
Yasser Almansour, Lane Donaldson, Khaled Kashlan, Swapna Vemuri, Jun Jin, John R. Craig   +5 more
wiley   +1 more source

Blepharoplasty: A Periorbital Rejuvenation Technique

, 2021
Facial rejuvenation procedure is one of the most desired at aesthetic plastic surgery. The orbital area with its inferior fat bags and prominent lacrimal sulcus suggests an elderly and tired appearance.
Mazzetti, Marcelo Paulo Vaccari, Ryane Schmidt Brock, Brock, Ryane Schmidt [UNESP], Marcelo Paulo Vaccari Mazzetti   +3 more
core   +1 more source

Improvement in Patient‐Reported Outcomes, High Rate of Return to Sport, and Secondary Surgery Rate Ranging From 0% to 9.8% After Hip Arthroscopy in Dancers and Athletes in Flexibility Sports: A Systematic Review

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To systematically review and report patient‐reported outcome measures (PROMs), rates of return to sport, and secondary surgeries in dancers and flexibility sport athletes who underwent hip arthroscopy. Methods Using the 2020 Preferred Reporting Items for Systematic Reviews and Meta‐Analyses criteria, a systematic review was performed with a ...
David R. Maldonado, Andrew R. Schab, Benjamin G. Domb   +2 more
wiley   +1 more source