Results 141 to 150 of about 30,495 (254)
Peptide binding at the gasdermin D exosite reveals the structural basis for targeting the site
Acta Crystallographica Section D, Volume 82, Issue 6, Page 615-625, June 2026.We describe the first structure of gasdermin D with a putative caspase inhibitor peptide analog at 1.6 Å resolution. This work suggests potential druggability of gasdermin D at the exosite by leveraging structure‐based computational design with biochemical characterization.Gasdermin D (GSDMD) has been identified as a critical component of the ...
Renjing Wang +15 more
wiley +1 more source
NACA 2412 performance modification via using AFC
, 2017 The NACA 2412 profile was numerically studied via employing 2D-DNS and implementing Active Flow Control (AFC), the Reynolds number considered was 6757, being the angle of attack of 8º.
Wierschem, Andreas +4 more
core +1 more source
Refined AFC-Enabled High-Lift System Integration Study
, 2016 A prior trade study established the effectiveness of using Active Flow Control (AFC) for reducing the mechanical complexities associated with a modern high-lift system without sacrificing aerodynamic performance at low-speed flight conditions ...
Shmilovich, Arvin +6 more
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Aging Cell, Volume 25, Issue 6, June 2026.Metabolic stress induces insulin resistance and upregulates PTP1B in granulosa cells, leading to aging‐relevant ovarian dysfunction. Gengnianchun (GNC) suppresses PTP1B, restores IRS1–AKT2–GLUT4 signaling, and preserves follicles, highlighting PTP1B as a therapeutic target for ovarian dysfunction in metabolically vulnerable states.
Yanqiu Rao +6 more
wiley +1 more source
Austral Ecology, Volume 51, Issue 6, June 2026.ABSTRACT Understanding animal distribution is crucial for elucidating natural history, population dynamics, and inter‐ and intraspecific interactions. This knowledge informs the planning and evaluation of management and conservation strategies, particularly for sympatric, scarce, and threatened species such as jaguars (Panthera onca) and pumas (Puma ...
Ricardo Corassa Arrais +4 more
wiley +1 more source
Performance et juste valeur: La communication financière des établissements de crédit
, 2004 International audienceDès le 1er janvier 2005, les normes comptables applicables aux établissements de crédit cotés membres de l'Union européenne seront celles produites par l'IASB. Ces normes accordent une part croissante à la juste valeur.
Escaffre, Lionel +1 more
core
AFC analogs as ICMT inhibitors
, 2005 Isoprenyl cysteine methyltransferase (Icmt) is a membrane bound enzyme that catalyzes the methyl esterification of Ras. This methyl esterification is important in the proper localization of Ras to the plasma membrane, and thus its biological activity ...
Henriksen, Brian S
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