Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale+9 more
wiley +1 more source
Dementia caregiving in India: New evidence from a National representative sample. [PDF]
Angrisani M, Reed NS, Banerjee J, Lee J.
europepmc +1 more source
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu+3 more
wiley +1 more source
Exploring the longitudinal relationships between non-suicidal self-injury and depressive symptoms in adolescents: a cross-lagged panel network analysis. [PDF]
Jia Q+8 more
europepmc +1 more source
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld+7 more
wiley +1 more source
Parenting Knowledge of Urban Chinese Postpartum Women: The Role of Spousal Support and Women's Affective Well-Being. [PDF]
He S, Chen Y.
europepmc +1 more source
Income of the American People, (an examination of the relation between the individual's income and the social and economic factors which affect it.) par HERMAN-P. MILLER. Un vol., 6 po. x 9¼, relié, 206 pages, JOHN WILEY & SONS, INC., 440 Fourth Avenue, New-York 16, 1955 ($5.50) [PDF]
Pierre D. Harvey
openalex +1 more source
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso+12 more
wiley +1 more source
SerenA:a multi-site pervasive agent environment that supports serendipitous discovery in research [PDF]
Aylett, Ruth+9 more
core +3 more sources
We assessed the associations between the gut microbiota and outcome in metastatic triple‐negative breast cancer patients treated with chemotherapy alone or chemotherapy in combination with immunotherapy. Our data indicate that high gut microbiota alpha diversity was associated with improved clinical outcome and with benefit from immunotherapy.
Andreas Ullern+8 more
wiley +1 more source