Results 101 to 110 of about 161,242 (287)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Affective Computing for Learning in Education: A Systematic Review and Bibliometric Analysis
Education SciencesAffective computing is an emerging area of education research and has the potential to enhance educational outcomes. Despite the growing number of literature studies, there are still deficiencies and gaps in the domain of affective computing in education.
Rajamanickam Yuvaraj +3 more
doaj +1 more source
Editorial: Transactions on Affective Computing – Affective Computing in the Times of Pandemics [PDF]
IEEE Transactions on Affective Computing, 2021 openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Discovering Gender Differences in Facial Emotion Recognition via Implicit Behavioral Cues
, 2017 We examine the utility of implicit behavioral cues in the form of EEG brain signals and eye movements for gender recognition (GR) and emotion recognition (ER). Specifically, the examined cues are acquired via low-cost, off-the-shelf sensors.
Bilalpur, Maneesh +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Agree to Disagree: Improving Disagreement Detection with Dual GRUs
, 2017 This paper presents models for detecting agreement/disagreement in online discussions. In this work we show that by using a Siamese inspired architecture to encode the discussions, we no longer need to rely on hand-crafted features to exploit the meta ...
Duppada, Venkatesh, Hiray, Sushant
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source