Results 131 to 140 of about 1,954,648 (281)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Affective Computing Based on Morphological Features of Photoplethysmography for Patients with Hypertension. [PDF]

Sensors (Basel), 2022
Yu SN, Lin IM, Wang SY, Hou YC, Yao SP, Lee CY, Chang CJ, Chu CS, Lin TH.   +8 more
europepmc   +1 more source

Foundation of Affective Computing and Interaction

CoRR
This book provides a comprehensive exploration of affective computing and human-computer interaction technologies. It begins with the historical development and basic concepts of human-computer interaction, delving into the technical frameworks and practical applications of emotional computing, visual interaction, voice interaction, brain-computer ...
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Designing Emotionally Adaptive Interfaces: Affective Ux Model For Enhancing Engagement In Gamified Learning Apps

International Journal of Graphic Design
In the digital learning era, user engagement is shaped not only by functionality and aesthetics but also by how interfaces adapt to users’ emotional experiences.
Adjeng Rahayu Dinata, Firli Hardiansyah, Juita Fitriana Sari   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Assessing Feasibility of Cognitive Impairment Testing Using Social Robotic Technology Augmented with Affective Computing and Emotional State Detection Systems. [PDF]

Biomimetics (Basel), 2023
Russo S, Lorusso L, D'Onofrio G, Ciccone F, Tritto M, Nocco S, Cardone D, Perpetuini D, Lombardo M, Lombardo D, Sancarlo D, Greco A, Merla A, Giuliani F.   +13 more
europepmc   +1 more source

InterARM: Interpretable Affective Reasoning Model for Multimodal Sarcasm Detection

Multimodal sarcasm detection (MSD) aims to identify sarcastic expressions by integrating multimodal and contextual cues to capture cross-modal semantic inconsistencies.
Yue, Tan, Cambria, Erik, Mao, Rui, Shi, Xuzhao   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source