Results 111 to 120 of about 952,740 (352)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Electrophysiological Correlates of Basic and Higher Order Cognitive and Affective Theory of Mind Processing in Emerging and Early Adulthood—An Explorative Event-Related Potentials Study to Investigate First-, Second-, and Third-Order Theory of Mind Processing Based on Visual Cues [PDF]

, 2020
Benjamin Tesar, Matthias Deckert, Michaela Schmoeger, Ulrike Willinger   +3 more
openalex   +1 more source

Cognitive Interpretation of Kant’s Theory of Aesthetic ideas [PDF]

, 2019
The aim of my paper is to argue that Kant’s aesthetic ideas can help us to overcome cognitive limitations that we often experience in our attempts to articulate the meaning of abstract concepts. I claim that aesthetic ideas, as expressed in works of art,
Kuplen, Mojca
core   +2 more sources

Touching the void: affective history and the impossible [PDF]

, 2010
In order to understand the persistence of History, we need to understand the appeal of historical work, its pleasures. Without such an understanding, theory and research will continue to talk at cross purposes, the one insisting that the past is ...
Robinson, Emily
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The racist bodily imaginary: the image of the body-in-pieces in (post)apartheid culture [PDF]

, 2013
This paper outlines a reoccurring motif within the racist imaginary of (post)apartheid culture: the black body-in-pieces. This disturbing visual idiom is approached from three conceptual perspectives.
A Krog, A Latham, A Mbembe, B Massumi, B St Louis, C Hemmings, D Hook, D Hook, Derek Hook, EK Sedgwick, F Fanon, G Deleuze, G Deleuze, G Deleuze, G Marinovich, H Strauss, J Butler, J Lacan, L Blackman, M Featherstone, NS Ndebele, O Stuart, P Godwin, P Pigou, PT Clough, R Barthes, R Coleman, R Coleman, R Coleman, S Alaimo, S Hill, S Kilpatrick, S Sontag, S žižek, S žižek   +34 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

FILM FESTIVAL POLITICS AND SPECTATORSHIP (NETWORK AFFECTS)

Studia Universitatis Babeș-Bolyai. Philosophia, 2016
Film Festival Politics and Spectatorship (Network Affects). The article is highly relevant for the relatively recent field of film festival research, and has a more limited relevance for the fields of film theory and philosophy of film.
Péter VIRGINÁS
doaj  

Dispositional Source of Job Satisfaction: The Role of Self-Deception [PDF]

, 1994
Despite providing strong indication that there is a dispositional source of job satisfaction, past research has not fully addressed the cardinal questions of how--or what--dispositions influence job satisfaction.
Erez, Amir, Judge, Timothy A.
core   +1 more source