Results 121 to 130 of about 952,740 (352)

Metacognition and headache: which Is the role in childhood and adolescence? [PDF]

open access: yes, 2017
Headache, in particular migraine, is one of the most frequent neurological symptoms in children and adolescents and it affects about 60% of children and adolescents all over the world.
Calderoni, D   +5 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Fluctuation of cognitive-emotional states during competition:an idiographic account [PDF]

open access: yes, 2007
The purpose of this paper is to describe athletes’ cognitive-emotional processes during competitions through an idiographic and ecologically valid study method based on verbal protocols and event sequential analyses.
Calmeiro, Luis, Tenenbaum, Gershon
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

From normal brain and behavior to schzophrenia [PDF]

open access: yes, 2003
Air Force Office of Scientific Research (F49620-01-1-0397); Office of Naval Research (N00014-01-1 ...
Grossberg, Stephen
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Features of Social Cognition in Late Adulthood

open access: yesСоциальная психология и общество, 2015
The paper presents outcomes of researches on the central component of social cognition — theory of mind in late adulthood. The outcomes show that, in normal aging, in advanced adulthood (55—74 years) as well as in old age (75—90 years) there are several ...
Melehin A.I., Sergienko E.A.
doaj   +1 more source

The Effect of Dysfunctional Thought Processes on Subjective Well-Being and Job Satisfaction [PDF]

open access: yes, 1992
While the dispositional approach to job satisfaction has received a good deal of recent attention, a fundamental deficiency in past dispositional research is a failure to use existing theories to explain why individuals are unhappy and dissatisfied with ...
Judge, Timothy A., Locke, Edwin A.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Unraveling the impact of customer mistreatment on highway toll collectors’ turnover intentions: the roles of stress symptoms, affective commitment, and neuroticism

open access: yesFrontiers in Psychology
In the service industry, highway toll collectors serve as a distinctive frontline workforce who frequently encounter mistreatment from customers. Unfortunately, these behaviors have not received the attention and resolution they deserve, resulting in ...
Yongduan Gao   +4 more
doaj   +1 more source

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