Results 131 to 140 of about 952,740 (352)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Putting the Horse Before the Cart: The Influence of Trigger Events on Justice Perceptions and Work Attitudes [PDF]
, 2017 To date very little research on organizational justice and work attitudes has focused on what starts the process that leads to these perceptions. A considerable amount of organizational research is focused on the end result (e.g., employees’ perceptions,
Cotton, John L., O\u27Neill, Bonnie S.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in PsychologyIntroductionTo enhance competitiveness, numerous organizations have introduced control and penalty systems to manage employee work errors. However, these systems have often backfired, negatively impacting employees’ emotions and behaviors.
Yuan Zhang, Jingqun Zhang, Kui Hao
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Behavioral SciencesInterpersonal workplace mistreatment (IWM) is a pervasive issue with varied co-worker reactions. Despite significant growth in IWM research, understanding co-workers’ responses remains challenging due to scattered research streams and a focus on isolated
Caroline Veronique Marijke Bastiaensen +2 more
doaj +1 more source
Evaluation of Nurses’ Job Engagement as an Outcome of Experienced Compassion in the Workplace, Using the Lens of Affective Event Theory [PDF]
, 2021 Muhammad Nadim, Mueen Aizaz Zafar
openalex +1 more source
Affect and believability in game characters:a review of the use of affective computing in games [PDF]
, 2017 Virtual agents are important in many digital environments. Designing a character that highly engages users in terms of interaction is an intricate task constrained by many requirements.
ElSayed, Salma, King, David J.
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source