Results 71 to 80 of about 1,889,584 (290)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Affective incoherence: when affective concepts and embodied reactions clash. [PDF]

, 2009
In five studies, the authors examined the effects on cognitive performance of coherence and incoherence between conceptual and experiential sources of affective information.
Centerbar, David B., Clore, Gerald L., Garvin, Erika D., Schnall, Simone   +3 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Antidepressant Drugs and Physical Activity: A Possible Synergism in the Treatment of Major Depression?

Frontiers in Psychology, 2020
Major depressive disorder (MDD) is a severe mental illness that affects 5–20% of the general population. Current antidepressant drugs exert only a partial clinical efficacy because approximately 30% of depressed patients failed to respond to these drugs ...
Claudia Savia Guerrera, Claudia Savia Guerrera, Giovanna Furneri, Giovanna Furneri, Margherita Grasso, Margherita Grasso, Giuseppe Caruso, Sabrina Castellano, Filippo Drago, Santo Di Nuovo, Filippo Caraci, Filippo Caraci   +11 more
doaj   +1 more source

The Physical Work Environment in relation to the Physical and Psychological Symptoms of Sick Building Syndrome [PDF]

, 2011
This study investigated the relationship between perceptions of a poor physical work environment (PWE) and sick building syndrome (SBS), and with various psychological variables that impact organizational productivity.
Meikle, Sarah Marie
core  

Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring [PDF]

, 2009
Background Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology. Aims To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring ...
David Gunnell, Dieter Wolke, Jeremy Horwood, Kate Thomas, Andrew Thompson, Gunnell, David, Lewis, Glyn, Harrison, Glynn, Stanley Zammit, Paulo Menezes, Hollis, Chris, Glyn Lewis, Wolke, Dieter, Zammit, Stanley, Horwood, Jeremy, Thomas, Kate, Thompson, Andrew D., Menezes, Paulo, Chris Hollis, Glynn Harrison, Thompson, Andrew   +20 more
core   +1 more source

Affective temperament and mood spectrum symptoms in workers suffering from work-related stress disorders

, 2022
Adjustment Disorders (AD) which develop in response to work-related stressors represent a model of psychiatric occupational disease. Major Depressive Episodes (MDE) although often associated to work-related stressors are unlikely recognized by insurance ...
Foddis, Rudy, Chiumiento, Martina, Caldi, Fabrizio, Veltri, Antonello, Guglielmi, Giovanni, Carmassi, Claudia, Corsi, Martina, Baldanzi, Sigrid, Dell'Osso, Liliana, Buselli, Rodolfo, Marino, Riccardo, Cristaudo, Alfonso   +11 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Beyond diagnosis: symptom patterns across complex PTSD and borderline personality disorder

Frontiers in Psychiatry
BackgroundComplex post-traumatic stress disorder (cPTSD) and borderline personality disorder (BPD) share overlapping clinical features, complicating accurate diagnosis and treatment. This overlap has fueled ongoing discussions regarding whether cPTSD and
Joe J. Simon, Joe J. Simon, Kristin Spiegler, Kadiatou Coulibaly, Marion A. Stopyra, Marion A. Stopyra, Hans-Christoph Friederich, Hans-Christoph Friederich, Oliver Gruber, Christoph Nikendei   +9 more
doaj   +1 more source