Results 71 to 80 of about 466,821 (308)

Designing and Testing a Model of Some Precedents and Outcomes of Borderline Personality Disorder in High School Students of Shiraz [PDF]

International Journal of School Health, 2015
Background: Borderline Personality Disorder (BPD) characterized by emotion dysregulation, disturbed interpersonal relationship, unstable sense of self, affect and behavior, is a severe disorder with a reported suicide rate 50 times the general population.
Seyede Fateme Sajadi, Yadolla Zargar, Mahnaz Mehrabizade Honarmand, Nasrin Arshadi   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Serum levels of S100B in patients with chronic schizophrenia during treatment augmentation with sarcosine: results of the double-blind, randomized, placebo-controlled PULSAR study

Frontiers in Pharmacology
IntroductionSarcosine (N-methylglycine) normalizes glutamatergic neurotransmission in schizophrenia and ameliorates primary negative symptoms. This amino acid may also directly or indirectly influence glial function and therefore levels of S100B, calcium-
Agnieszka Pawlak, Adam Wysokiński, Dominik Strzelecki   +2 more
doaj   +1 more source

The Negativity Bias Predicts Response Rate To Behavioral Activation For Depression [PDF]

, 2016
Background and Objectives: This treatment study investigated the extent to which asymmetric dimensions of affective responding, specifically the positivity offset and the negativity bias, at pretreatment altered the rate of response to Behavioral ...
Cacioppo, J., Gollan, J. K., Hoxha, D., Hunnicutt-Ferguson, K., Norris, Catherine, Rosebrock, L., Sankin, L.   +6 more
core   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Specificity of affective dynamics of bipolar and major depressive disorder

Brain and Behavior, 2023
Objective Here, we examine whether the dynamics of the four dimensions of the circumplex model of affect assessed by ecological momentary assessment (EMA) differ among those with bipolar disorder (BD) and major depressive disorder (MDD).
Emma K. Stapp, Vadim Zipunnikov, Andrew Leroux, Lihong Cui, Mathilde M. Husky, Debangan Dey, Kathleen R. Merikangas   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The relationship between cognitive and affective control and symptoms of depression and anxiety across the lifespan: A 3-wave longitudinal study

Comprehensive Psychiatry
Introduction: The association between cognitive functioning and mental health symptoms across the lifespan remains poorly understood. Understanding the directionality of the association between mental health and cognition is important as most gold ...
Anson Kai Chun Chau, Savannah Minihan, Sakiko Okayama, Susanne Schweizer   +3 more
doaj   +1 more source

Unseen Affective Faces Influence Person Perception Judgments in Schizophrenia. [PDF]

, 2014
To demonstrate the influence of unconscious affective processing on consciously processed information among people with and without schizophrenia, we used a continuous flash suppression (CFS) paradigm to examine whether early and rapid processing of ...
Barrett, Lisa Feldman, Kring, Ann M, Siegel, Erika H   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source