Results 81 to 90 of about 1,967,901 (293)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

The Problem of Qualifying Affective Symptoms in the Differential Diagnosis of Mental Disorders

Теоретическая и экспериментальная психология
Background. Currently, there is a growing number of diagnosed mental disorders worldwide. The specialist conducting the diagnosis works under time constraints as determined by regulations per patient.
Leonora S. Pechnikova, Anna V. Petukhova, Ivan A. Gorbatenko   +2 more
doaj   +1 more source

Study of alexithymia among people with low distress tolerance compared to non-clinical sample

Social Determinants of Health, 2017
Background: Alexithymia is a personality construct described as an asymptomatic clinical disability to identify and describe individual feelings. Individuals with alexithymia have difficulties regarding distress tolerance.
Sajjad Heydarian, Edris Azami, Afshar Sahraei, Akbar Mohammadi, Mohsen Rezaei   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Beyond diagnosis: symptom patterns across complex PTSD and borderline personality disorder

Frontiers in Psychiatry
BackgroundComplex post-traumatic stress disorder (cPTSD) and borderline personality disorder (BPD) share overlapping clinical features, complicating accurate diagnosis and treatment. This overlap has fueled ongoing discussions regarding whether cPTSD and
Joe J. Simon, Joe J. Simon, Kristin Spiegler, Kadiatou Coulibaly, Marion A. Stopyra, Marion A. Stopyra, Hans-Christoph Friederich, Hans-Christoph Friederich, Oliver Gruber, Christoph Nikendei   +9 more
doaj   +1 more source

Disentangling the Role of Working Memory in Parkinson’s Disease

Frontiers in Aging Neuroscience, 2020
Working memory (WM) represents a core cognitive function with a major striatal contribution, and thus WM deficits, commonly observed in Parkinson’s disease (PD), could also relate to many other problems in PD patients. Our online study aimed to determine
Juha Salmi, Juha Salmi, Juha Salmi, Juha Salmi, Liisa Ritakallio, Daniel Fellman, Daniel Fellman, Ulla Ellfolk, Ulla Ellfolk, Juha O. Rinne, Juha O. Rinne, Matti Laine, Matti Laine   +12 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Is Emotional Allodynia in Fibromyalgia Reducible to Depression? A Preliminary Network Analysis in 149 Patients

Medical Sciences
Background/Objectives: Because affect is challenging to quantify in fibromyalgia, previous network analyses have primarily relied on symptom-severity measures, whereas emotion regulation and affective hypersensitivity have rarely been included.
Alberto Corriero, Mariateresa Giglio, Alfonso Pilolla, Filomena Galdini, Cinzia Di Venosa, Elisabetta Costantino, Daniela De Orsi, Giustino Varrassi, Paolo Trerotoli, Filomena Puntillo   +9 more
doaj   +1 more source

Is type of depressive symptoms associated with patient-perceived need for professional psychological care in depressed individuals with diabetes?

PLoS ONE, 2019
AimsThe objective of this study is to investigate whether type of depressive symptoms (i.e. cognitive-affective or somatic) is related to a patient-perceived need for professional psychological care in individuals with diabetes.MethodsIn total 2266 ...
L J van der Donk, J Fleer, R Sanderman, P M G Emmelkamp, T P Links, K A Tovote, M J Schroevers   +6 more
doaj   +1 more source

Physical Activity Decreases Somatic Symptom Distress in the Affect and Symptom Paradigm

Biopsychosocial Science and Medicine
Objective: According to recent empirical taxonomies (eg, the Hierarchical Taxonomy of Psychopathology), somatic symptom distress represents a transdiagnostically relevant dimension of psychopathology. To better understand the mechanisms, somatic symptoms can be experimentally provoked by inducing negative affect (in the Affect ...
Petzke, Tara M., Köteles, Ferenc, Van den Bergh, Omer, Witthöft, Michael   +3 more
openaire   +5 more sources